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Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
We sought to identify new susceptibility loci for Alzheimer’s disease (AD) through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer’s Disease Genetic Consortium (ADGC). First, we undertook a combined analysis of four genome-wide association datasets (Stage...
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| Formato: | Texto |
| Lenguaje: | English |
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2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084173/ https://www.ncbi.nlm.nih.gov/pubmed/21460840 http://dx.doi.org/10.1038/ng.803 |
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| author | Hollingworth, Paul Harold, Denise Sims, Rebecca Gerrish, Amy Lambert, Jean-Charles Carrasquillo, Minerva M Abraham, Richard Hamshere, Marian L Pahwa, Jaspreet Singh Moskvina, Valentina Dowzell, Kimberley Jones, Nicola Stretton, Alexandra Thomas, Charlene Richards, Alex Ivanov, Dobril Widdowson, Caroline Chapman, Jade Lovestone, Simon Powell, John Proitsi, Petroula Lupton, Michelle K Brayne, Carol Rubinsztein, David C Gill, Michael Lawlor, Brian Lynch, Aoibhinn Brown, Kristelle S Passmore, Peter A Craig, David McGuinness, Bernadette Todd, Stephen Holmes, Clive Mann, David Smith, A David Beaumont, Helen Warden, Donald Wilcock, Gordon Love, Seth Kehoe, Patrick G Hooper, Nigel M Vardy, Emma R. L. C. Hardy, John Mead, Simon Fox, Nick C Rossor, Martin Collinge, John Maier, Wolfgang Jessen, Frank Schürmann, Britta Rüther, Eckart Heun, Reiner Kölsch, Heike van den Bussche, Hendrik Heuser, Isabella Kornhuber, Johannes Wiltfang, Jens Dichgans, Martin Frölich, Lutz Hampel, Harald Hüll, Michael Gallacher, John Rujescu, Dan Giegling, Ina Goate, Alison M Kauwe, John S K Cruchaga, Carlos Nowotny, Petra Morris, John C Mayo, Kevin Sleegers, Kristel Bettens, Karolien Engelborghs, Sebastiaan De Deyn, Peter P Van Broeckhoven, Christine Livingston, Gill Bass, Nicholas J Gurling, Hugh McQuillin, Andrew Gwilliam, Rhian Deloukas, Panagiotis Al-Chalabi, Ammar Shaw, Christopher E Tsolaki, Magda Singleton, Andrew B Guerreiro, Rita Mühleisen, Thomas W Nöthen, Markus M Moebus, Susanne Jöckel, Karl-Heinz Klopp, Norman Wichmann, H-Erich Pankratz, V Shane Sando, Sigrid B Aasly, Jan O Barcikowska, Maria Wszolek, Zbigniew K Dickson, Dennis W Graff-Radford, Neill R Petersen, Ronald C van Duijn, Cornelia M Breteler, Monique MB Ikram, M Arfan DeStefano, Anita L Fitzpatrick, Annette L Lopez, Oscar Launer, Lenore J Seshadri, Sudha Berr, Claudine Campion, Dominique Epelbaum, Jacques Dartigues, Jean-François Tzourio, Christophe Alpérovitch, Annick Lathrop, Mark Feulner, Thomas M Friedrich, Patricia Riehle, Caterina Krawczak, Michael Schreiber, Stefan Mayhaus, Manuel Nicolhaus, S Wagenpfeil, Stefan Steinberg, Stacy Stefansson, Hreinn Stefansson, Kari Snædal, Jon Björnsson, Sigurbjörn Jonsson, Palmi V. Chouraki, Vincent Genier-Boley, Benjamin Hiltunen, Mikko Soininen, Hilkka Combarros, Onofre Zelenika, Diana Delepine, Marc Bullido, Maria J Pasquier, Florence Mateo, Ignacio Frank-Garcia, Ana Porcellini, Elisa Hanon, Olivier Coto, Eliecer Alvarez, Victoria Bosco, Paolo Siciliano, Gabriele Mancuso, Michelangelo Panza, Francesco Solfrizzi, Vincenzo Nacmias, Benedetta Sorbi, Sandro Bossù, Paola Piccardi, Paola Arosio, Beatrice Annoni, Giorgio Seripa, Davide Pilotto, Alberto Scarpini, Elio Galimberti, Daniela Brice, Alexis Hannequin, Didier Licastro, Federico Jones, Lesley Holmans, Peter A Jonsson, Thorlakur Riemenschneider, Matthias Morgan, Kevin Younkin, Steven G Owen, Michael J O’Donovan, Michael Amouyel, Philippe Williams, Julie |
| author_facet | Hollingworth, Paul Harold, Denise Sims, Rebecca Gerrish, Amy Lambert, Jean-Charles Carrasquillo, Minerva M Abraham, Richard Hamshere, Marian L Pahwa, Jaspreet Singh Moskvina, Valentina Dowzell, Kimberley Jones, Nicola Stretton, Alexandra Thomas, Charlene Richards, Alex Ivanov, Dobril Widdowson, Caroline Chapman, Jade Lovestone, Simon Powell, John Proitsi, Petroula Lupton, Michelle K Brayne, Carol Rubinsztein, David C Gill, Michael Lawlor, Brian Lynch, Aoibhinn Brown, Kristelle S Passmore, Peter A Craig, David McGuinness, Bernadette Todd, Stephen Holmes, Clive Mann, David Smith, A David Beaumont, Helen Warden, Donald Wilcock, Gordon Love, Seth Kehoe, Patrick G Hooper, Nigel M Vardy, Emma R. L. C. Hardy, John Mead, Simon Fox, Nick C Rossor, Martin Collinge, John Maier, Wolfgang Jessen, Frank Schürmann, Britta Rüther, Eckart Heun, Reiner Kölsch, Heike van den Bussche, Hendrik Heuser, Isabella Kornhuber, Johannes Wiltfang, Jens Dichgans, Martin Frölich, Lutz Hampel, Harald Hüll, Michael Gallacher, John Rujescu, Dan Giegling, Ina Goate, Alison M Kauwe, John S K Cruchaga, Carlos Nowotny, Petra Morris, John C Mayo, Kevin Sleegers, Kristel Bettens, Karolien Engelborghs, Sebastiaan De Deyn, Peter P Van Broeckhoven, Christine Livingston, Gill Bass, Nicholas J Gurling, Hugh McQuillin, Andrew Gwilliam, Rhian Deloukas, Panagiotis Al-Chalabi, Ammar Shaw, Christopher E Tsolaki, Magda Singleton, Andrew B Guerreiro, Rita Mühleisen, Thomas W Nöthen, Markus M Moebus, Susanne Jöckel, Karl-Heinz Klopp, Norman Wichmann, H-Erich Pankratz, V Shane Sando, Sigrid B Aasly, Jan O Barcikowska, Maria Wszolek, Zbigniew K Dickson, Dennis W Graff-Radford, Neill R Petersen, Ronald C van Duijn, Cornelia M Breteler, Monique MB Ikram, M Arfan DeStefano, Anita L Fitzpatrick, Annette L Lopez, Oscar Launer, Lenore J Seshadri, Sudha Berr, Claudine Campion, Dominique Epelbaum, Jacques Dartigues, Jean-François Tzourio, Christophe Alpérovitch, Annick Lathrop, Mark Feulner, Thomas M Friedrich, Patricia Riehle, Caterina Krawczak, Michael Schreiber, Stefan Mayhaus, Manuel Nicolhaus, S Wagenpfeil, Stefan Steinberg, Stacy Stefansson, Hreinn Stefansson, Kari Snædal, Jon Björnsson, Sigurbjörn Jonsson, Palmi V. Chouraki, Vincent Genier-Boley, Benjamin Hiltunen, Mikko Soininen, Hilkka Combarros, Onofre Zelenika, Diana Delepine, Marc Bullido, Maria J Pasquier, Florence Mateo, Ignacio Frank-Garcia, Ana Porcellini, Elisa Hanon, Olivier Coto, Eliecer Alvarez, Victoria Bosco, Paolo Siciliano, Gabriele Mancuso, Michelangelo Panza, Francesco Solfrizzi, Vincenzo Nacmias, Benedetta Sorbi, Sandro Bossù, Paola Piccardi, Paola Arosio, Beatrice Annoni, Giorgio Seripa, Davide Pilotto, Alberto Scarpini, Elio Galimberti, Daniela Brice, Alexis Hannequin, Didier Licastro, Federico Jones, Lesley Holmans, Peter A Jonsson, Thorlakur Riemenschneider, Matthias Morgan, Kevin Younkin, Steven G Owen, Michael J O’Donovan, Michael Amouyel, Philippe Williams, Julie |
| author_sort | Hollingworth, Paul |
| collection | PubMed |
| description | We sought to identify new susceptibility loci for Alzheimer’s disease (AD) through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer’s Disease Genetic Consortium (ADGC). First, we undertook a combined analysis of four genome-wide association datasets (Stage 1) and identified 10 novel variants with P≤1×10(−5). These were tested for association in an independent sample (Stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (Stage 3). Meta-analyses of all data provide compelling evidence that ABCA7 (meta-P 4.5×10(−17); including ADGC meta-P=5.0×10(−21)) and the MS4A gene cluster (rs610932, meta-P=1.8×10(−14); including ADGC meta-P=1.2×10(−16); rs670139, meta-P=1.4×10(−9); including ADGC meta-P=1.1×10(−10)) are novel susceptibility loci for AD. Second, we observed independent evidence for association for three suggestive loci reported by the ADGC GWAS, which when combined shows genome-wide significance: CD2AP (GERAD+ P=8.0×10(−4); including ADGC meta-P=8.6×10(−9)), CD33 (GERAD+ P=2.2×10(−4); including ADGC meta-P=1.6×10(−9)) and EPHA1 (GERAD+ P=3.4×10(−4); including ADGC meta-P=6.0×10(−10)). These findings support five novel susceptibility genes for AD. |
| format | Text |
| id | pubmed-3084173 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30841732011-11-01 Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease Hollingworth, Paul Harold, Denise Sims, Rebecca Gerrish, Amy Lambert, Jean-Charles Carrasquillo, Minerva M Abraham, Richard Hamshere, Marian L Pahwa, Jaspreet Singh Moskvina, Valentina Dowzell, Kimberley Jones, Nicola Stretton, Alexandra Thomas, Charlene Richards, Alex Ivanov, Dobril Widdowson, Caroline Chapman, Jade Lovestone, Simon Powell, John Proitsi, Petroula Lupton, Michelle K Brayne, Carol Rubinsztein, David C Gill, Michael Lawlor, Brian Lynch, Aoibhinn Brown, Kristelle S Passmore, Peter A Craig, David McGuinness, Bernadette Todd, Stephen Holmes, Clive Mann, David Smith, A David Beaumont, Helen Warden, Donald Wilcock, Gordon Love, Seth Kehoe, Patrick G Hooper, Nigel M Vardy, Emma R. L. C. Hardy, John Mead, Simon Fox, Nick C Rossor, Martin Collinge, John Maier, Wolfgang Jessen, Frank Schürmann, Britta Rüther, Eckart Heun, Reiner Kölsch, Heike van den Bussche, Hendrik Heuser, Isabella Kornhuber, Johannes Wiltfang, Jens Dichgans, Martin Frölich, Lutz Hampel, Harald Hüll, Michael Gallacher, John Rujescu, Dan Giegling, Ina Goate, Alison M Kauwe, John S K Cruchaga, Carlos Nowotny, Petra Morris, John C Mayo, Kevin Sleegers, Kristel Bettens, Karolien Engelborghs, Sebastiaan De Deyn, Peter P Van Broeckhoven, Christine Livingston, Gill Bass, Nicholas J Gurling, Hugh McQuillin, Andrew Gwilliam, Rhian Deloukas, Panagiotis Al-Chalabi, Ammar Shaw, Christopher E Tsolaki, Magda Singleton, Andrew B Guerreiro, Rita Mühleisen, Thomas W Nöthen, Markus M Moebus, Susanne Jöckel, Karl-Heinz Klopp, Norman Wichmann, H-Erich Pankratz, V Shane Sando, Sigrid B Aasly, Jan O Barcikowska, Maria Wszolek, Zbigniew K Dickson, Dennis W Graff-Radford, Neill R Petersen, Ronald C van Duijn, Cornelia M Breteler, Monique MB Ikram, M Arfan DeStefano, Anita L Fitzpatrick, Annette L Lopez, Oscar Launer, Lenore J Seshadri, Sudha Berr, Claudine Campion, Dominique Epelbaum, Jacques Dartigues, Jean-François Tzourio, Christophe Alpérovitch, Annick Lathrop, Mark Feulner, Thomas M Friedrich, Patricia Riehle, Caterina Krawczak, Michael Schreiber, Stefan Mayhaus, Manuel Nicolhaus, S Wagenpfeil, Stefan Steinberg, Stacy Stefansson, Hreinn Stefansson, Kari Snædal, Jon Björnsson, Sigurbjörn Jonsson, Palmi V. Chouraki, Vincent Genier-Boley, Benjamin Hiltunen, Mikko Soininen, Hilkka Combarros, Onofre Zelenika, Diana Delepine, Marc Bullido, Maria J Pasquier, Florence Mateo, Ignacio Frank-Garcia, Ana Porcellini, Elisa Hanon, Olivier Coto, Eliecer Alvarez, Victoria Bosco, Paolo Siciliano, Gabriele Mancuso, Michelangelo Panza, Francesco Solfrizzi, Vincenzo Nacmias, Benedetta Sorbi, Sandro Bossù, Paola Piccardi, Paola Arosio, Beatrice Annoni, Giorgio Seripa, Davide Pilotto, Alberto Scarpini, Elio Galimberti, Daniela Brice, Alexis Hannequin, Didier Licastro, Federico Jones, Lesley Holmans, Peter A Jonsson, Thorlakur Riemenschneider, Matthias Morgan, Kevin Younkin, Steven G Owen, Michael J O’Donovan, Michael Amouyel, Philippe Williams, Julie Nat Genet Article We sought to identify new susceptibility loci for Alzheimer’s disease (AD) through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer’s Disease Genetic Consortium (ADGC). First, we undertook a combined analysis of four genome-wide association datasets (Stage 1) and identified 10 novel variants with P≤1×10(−5). These were tested for association in an independent sample (Stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (Stage 3). Meta-analyses of all data provide compelling evidence that ABCA7 (meta-P 4.5×10(−17); including ADGC meta-P=5.0×10(−21)) and the MS4A gene cluster (rs610932, meta-P=1.8×10(−14); including ADGC meta-P=1.2×10(−16); rs670139, meta-P=1.4×10(−9); including ADGC meta-P=1.1×10(−10)) are novel susceptibility loci for AD. Second, we observed independent evidence for association for three suggestive loci reported by the ADGC GWAS, which when combined shows genome-wide significance: CD2AP (GERAD+ P=8.0×10(−4); including ADGC meta-P=8.6×10(−9)), CD33 (GERAD+ P=2.2×10(−4); including ADGC meta-P=1.6×10(−9)) and EPHA1 (GERAD+ P=3.4×10(−4); including ADGC meta-P=6.0×10(−10)). These findings support five novel susceptibility genes for AD. 2011-04-03 2011-05 /pmc/articles/PMC3084173/ /pubmed/21460840 http://dx.doi.org/10.1038/ng.803 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Hollingworth, Paul Harold, Denise Sims, Rebecca Gerrish, Amy Lambert, Jean-Charles Carrasquillo, Minerva M Abraham, Richard Hamshere, Marian L Pahwa, Jaspreet Singh Moskvina, Valentina Dowzell, Kimberley Jones, Nicola Stretton, Alexandra Thomas, Charlene Richards, Alex Ivanov, Dobril Widdowson, Caroline Chapman, Jade Lovestone, Simon Powell, John Proitsi, Petroula Lupton, Michelle K Brayne, Carol Rubinsztein, David C Gill, Michael Lawlor, Brian Lynch, Aoibhinn Brown, Kristelle S Passmore, Peter A Craig, David McGuinness, Bernadette Todd, Stephen Holmes, Clive Mann, David Smith, A David Beaumont, Helen Warden, Donald Wilcock, Gordon Love, Seth Kehoe, Patrick G Hooper, Nigel M Vardy, Emma R. L. C. Hardy, John Mead, Simon Fox, Nick C Rossor, Martin Collinge, John Maier, Wolfgang Jessen, Frank Schürmann, Britta Rüther, Eckart Heun, Reiner Kölsch, Heike van den Bussche, Hendrik Heuser, Isabella Kornhuber, Johannes Wiltfang, Jens Dichgans, Martin Frölich, Lutz Hampel, Harald Hüll, Michael Gallacher, John Rujescu, Dan Giegling, Ina Goate, Alison M Kauwe, John S K Cruchaga, Carlos Nowotny, Petra Morris, John C Mayo, Kevin Sleegers, Kristel Bettens, Karolien Engelborghs, Sebastiaan De Deyn, Peter P Van Broeckhoven, Christine Livingston, Gill Bass, Nicholas J Gurling, Hugh McQuillin, Andrew Gwilliam, Rhian Deloukas, Panagiotis Al-Chalabi, Ammar Shaw, Christopher E Tsolaki, Magda Singleton, Andrew B Guerreiro, Rita Mühleisen, Thomas W Nöthen, Markus M Moebus, Susanne Jöckel, Karl-Heinz Klopp, Norman Wichmann, H-Erich Pankratz, V Shane Sando, Sigrid B Aasly, Jan O Barcikowska, Maria Wszolek, Zbigniew K Dickson, Dennis W Graff-Radford, Neill R Petersen, Ronald C van Duijn, Cornelia M Breteler, Monique MB Ikram, M Arfan DeStefano, Anita L Fitzpatrick, Annette L Lopez, Oscar Launer, Lenore J Seshadri, Sudha Berr, Claudine Campion, Dominique Epelbaum, Jacques Dartigues, Jean-François Tzourio, Christophe Alpérovitch, Annick Lathrop, Mark Feulner, Thomas M Friedrich, Patricia Riehle, Caterina Krawczak, Michael Schreiber, Stefan Mayhaus, Manuel Nicolhaus, S Wagenpfeil, Stefan Steinberg, Stacy Stefansson, Hreinn Stefansson, Kari Snædal, Jon Björnsson, Sigurbjörn Jonsson, Palmi V. Chouraki, Vincent Genier-Boley, Benjamin Hiltunen, Mikko Soininen, Hilkka Combarros, Onofre Zelenika, Diana Delepine, Marc Bullido, Maria J Pasquier, Florence Mateo, Ignacio Frank-Garcia, Ana Porcellini, Elisa Hanon, Olivier Coto, Eliecer Alvarez, Victoria Bosco, Paolo Siciliano, Gabriele Mancuso, Michelangelo Panza, Francesco Solfrizzi, Vincenzo Nacmias, Benedetta Sorbi, Sandro Bossù, Paola Piccardi, Paola Arosio, Beatrice Annoni, Giorgio Seripa, Davide Pilotto, Alberto Scarpini, Elio Galimberti, Daniela Brice, Alexis Hannequin, Didier Licastro, Federico Jones, Lesley Holmans, Peter A Jonsson, Thorlakur Riemenschneider, Matthias Morgan, Kevin Younkin, Steven G Owen, Michael J O’Donovan, Michael Amouyel, Philippe Williams, Julie Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease |
| title | Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease |
| title_full | Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease |
| title_fullStr | Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease |
| title_full_unstemmed | Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease |
| title_short | Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease |
| title_sort | common variants in abca7, ms4a6a/ms4a4e, epha1, cd33 and cd2ap are associated with alzheimer’s disease |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084173/ https://www.ncbi.nlm.nih.gov/pubmed/21460840 http://dx.doi.org/10.1038/ng.803 |
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commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT guerreirorita commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT muhleisenthomasw commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT nothenmarkusm commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT moebussusanne commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT jockelkarlheinz commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT kloppnorman commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT wichmannherich commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT pankratzvshane commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT sandosigridb commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT aaslyjano commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT barcikowskamaria commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT wszolekzbigniewk commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT dicksondennisw commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT graffradfordneillr commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT petersenronaldc commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT vanduijncorneliam commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT bretelermoniquemb 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commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT jonssonpalmiv commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT chourakivincent commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT genierboleybenjamin commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT hiltunenmikko commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT soininenhilkka commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT combarrosonofre commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT zelenikadiana commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT delepinemarc commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT bullidomariaj commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT pasquierflorence commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT mateoignacio commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT frankgarciaana commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT porcellinielisa commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT hanonolivier commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT cotoeliecer commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT alvarezvictoria commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT boscopaolo commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT sicilianogabriele commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT mancusomichelangelo commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT panzafrancesco commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT solfrizzivincenzo commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT nacmiasbenedetta commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT sorbisandro commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT bossupaola commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT piccardipaola commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT arosiobeatrice commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT annonigiorgio commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT seripadavide commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT pilottoalberto commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT scarpinielio commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT galimbertidaniela commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT bricealexis commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT hannequindidier commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT licastrofederico commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT joneslesley commonvariantsinabca7ms4a6ams4a4eepha1cd33andcd2apareassociatedwithalzheimersdisease AT holmanspetera 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