Promiscuity and preferences of metallothioneins: the cell rules

Metalloproteins are essential for many cellular functions, but it has not been clear how they distinguish between the different metals to bind the correct ones. A report in BMC Biology finds that preferences of two metallothionein isoforms for two different cations are due to inherent properties of...

Descripción completa

Detalles Bibliográficos
Autores principales: Foster, Andrew W, Robinson, Nigel J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084178/
https://www.ncbi.nlm.nih.gov/pubmed/21527046
http://dx.doi.org/10.1186/1741-7007-9-25
_version_ 1782202464629424128
author Foster, Andrew W
Robinson, Nigel J
author_facet Foster, Andrew W
Robinson, Nigel J
author_sort Foster, Andrew W
collection PubMed
description Metalloproteins are essential for many cellular functions, but it has not been clear how they distinguish between the different metals to bind the correct ones. A report in BMC Biology finds that preferences of two metallothionein isoforms for two different cations are due to inherent properties of these usually less discriminating proteins. Here these observations are discussed in the context of the cellular mechanisms that regulate metal binding to proteins. See research article: http://www.biomedcentral.com/1741-7007/9/4
format Text
id pubmed-3084178
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-30841782011-04-29 Promiscuity and preferences of metallothioneins: the cell rules Foster, Andrew W Robinson, Nigel J BMC Biol Commentary Metalloproteins are essential for many cellular functions, but it has not been clear how they distinguish between the different metals to bind the correct ones. A report in BMC Biology finds that preferences of two metallothionein isoforms for two different cations are due to inherent properties of these usually less discriminating proteins. Here these observations are discussed in the context of the cellular mechanisms that regulate metal binding to proteins. See research article: http://www.biomedcentral.com/1741-7007/9/4 BioMed Central 2011-04-28 /pmc/articles/PMC3084178/ /pubmed/21527046 http://dx.doi.org/10.1186/1741-7007-9-25 Text en Copyright ©2011 Foster and Robinson; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Foster, Andrew W
Robinson, Nigel J
Promiscuity and preferences of metallothioneins: the cell rules
title Promiscuity and preferences of metallothioneins: the cell rules
title_full Promiscuity and preferences of metallothioneins: the cell rules
title_fullStr Promiscuity and preferences of metallothioneins: the cell rules
title_full_unstemmed Promiscuity and preferences of metallothioneins: the cell rules
title_short Promiscuity and preferences of metallothioneins: the cell rules
title_sort promiscuity and preferences of metallothioneins: the cell rules
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084178/
https://www.ncbi.nlm.nih.gov/pubmed/21527046
http://dx.doi.org/10.1186/1741-7007-9-25
work_keys_str_mv AT fosterandreww promiscuityandpreferencesofmetallothioneinsthecellrules
AT robinsonnigelj promiscuityandpreferencesofmetallothioneinsthecellrules

Ejemplares similares