NF-κB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti-Sense Protein HBZ

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Activation of I-κB kinases (IKKs) and NF-κB by the human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation. Paradoxically, expression of Tax in most cells leads to drastic up-regulation of cyclin-dependent kinase inhibi...

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Detalles Bibliográficos
Autores principales: Zhi, Huijun, Yang, Liangpeng, Kuo, Yu-Liang, Ho, Yik-Khuan, Shih, Hsiu-Ming, Giam, Chou-Zen
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084201/
https://www.ncbi.nlm.nih.gov/pubmed/21552325
http://dx.doi.org/10.1371/journal.ppat.1002025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084201/
https://www.ncbi.nlm.nih.gov/pubmed/21552325
http://dx.doi.org/10.1371/journal.ppat.1002025

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