Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum

Huntingtin is a large HEAT repeat protein first identified in humans, where a polyglutamine tract expansion near the amino terminus causes a gain-of-function mechanism that leads to selective neuronal loss in Huntington's disease (HD). Genetic evidence in humans and knock-in mouse models sugges...

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Detalles Bibliográficos
Autores principales: Myre, Michael A., Lumsden, Amanda L., Thompson, Morgan N., Wasco, Wilma, MacDonald, Marcy E., Gusella, James F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084204/
https://www.ncbi.nlm.nih.gov/pubmed/21552328
http://dx.doi.org/10.1371/journal.pgen.1002052

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