Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

DNA double-strand breaks (DSBs) are potent sources of genome instability. While there is considerable genetic and molecular information about the disposition of direct DSBs and breaks that arise during replication, relatively little is known about DSBs derived during processing of single-strand lesi...

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Detalles Bibliográficos
Autores principales: Ma, Wenjian, Westmoreland, Jim W., Gordenin, Dmitry A., Resnick, Mike A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084215/
https://www.ncbi.nlm.nih.gov/pubmed/21552545
http://dx.doi.org/10.1371/journal.pgen.1002059

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