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Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir

Nelfinavir is a potent HIV-protease inhibitor with pleiotropic effects in cancer cells. Experimental studies connect its anti-cancer effects to the suppression of the Akt signaling pathway, but the actual molecular targets remain unknown. Using a structural proteome-wide off-target pipeline, which i...

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Detalles Bibliográficos
Autores principales:	Xie, Li, Evangelidis, Thomas, Xie, Lei, Bourne, Philip E.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084228/ https://www.ncbi.nlm.nih.gov/pubmed/21552547 http://dx.doi.org/10.1371/journal.pcbi.1002037

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