Survey of Activated FLT3 Signaling in Leukemia

Activating mutations of FMS-like tyrosine kinase-3 (FLT3) are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 is therefore an attractive drug target. However, the molecular mechanisms by which FLT3 mutations lead to cell transformation in AML remain unclear. To develop...

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Detalles Bibliográficos
Autores principales: Gu, Ting-lei, Nardone, Julie, Wang, Yi, Loriaux, Marc, Villén, Judit, Beausoleil, Sean, Tucker, Meghan, Kornhauser, Jon, Ren, Jianmin, MacNeill, Joan, Gygi, Steven P., Druker, Brian J., Heinrich, Michael C., Rush, John, Polakiewicz, Roberto D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084268/
https://www.ncbi.nlm.nih.gov/pubmed/21552520
http://dx.doi.org/10.1371/journal.pone.0019169

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