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Alternative Splicing of the Cardiac Sodium Channel Creates Multiple Variants of Mutant T1620K Channels

Alternative splicing creates several Na(v)1.5 transcripts in the mammalian myocardium and in various other tissues including brain, dorsal root ganglia, breast cancer cells as well as neuronal stem cell lines. In total nine Na(v)1.5 splice variants have been discovered. Four of them, namely Na(v)1.5...

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Detalles Bibliográficos
Autores principales: Walzik, Stefan, Schroeter, Annett, Benndorf, Klaus, Zimmer, Thomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084281/
https://www.ncbi.nlm.nih.gov/pubmed/21552533
http://dx.doi.org/10.1371/journal.pone.0019188