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Genetic Analysis Reveals an Unexpected Role of BMP7 in Initiation of Ureteric Bud Outgrowth in Mouse Embryos

BACKGROUND: Genetic analysis in the mouse revealed that GREMLIN1 (GREM1)-mediated antagonism of BMP4 is essential for ureteric epithelial branching as the disruption of ureteric bud outgrowth and renal agenesis in Grem1-deficient embryos is restored by additional inactivation of one Bmp4 allele. Ano...

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Detalles Bibliográficos
Autores principales:	Gonçalves, Alexandre, Zeller, Rolf
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084290/ https://www.ncbi.nlm.nih.gov/pubmed/21552539 http://dx.doi.org/10.1371/journal.pone.0019370

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