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Expression of complement components, receptors and regulators by human dendritic cells

Integration of innate and adaptive arms of the immune response at a cellular and molecular level appears to be fundamental to the development of powerful effector functions in host defence and aberrant immune responses. Here we provide evidence that the functions of human complement activation and a...

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Autores principales: Li, Ke, Fazekasova, Henrieta, Wang, Naiyin, Sagoo, Pervinder, Peng, Qi, Khamri, Wafa, Gomes, Chantelle, Sacks, Steven H., Lombardi, Giovanna, Zhou, Wuding
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084445/
https://www.ncbi.nlm.nih.gov/pubmed/21397947
http://dx.doi.org/10.1016/j.molimm.2011.02.003
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author Li, Ke
Fazekasova, Henrieta
Wang, Naiyin
Sagoo, Pervinder
Peng, Qi
Khamri, Wafa
Gomes, Chantelle
Sacks, Steven H.
Lombardi, Giovanna
Zhou, Wuding
author_facet Li, Ke
Fazekasova, Henrieta
Wang, Naiyin
Sagoo, Pervinder
Peng, Qi
Khamri, Wafa
Gomes, Chantelle
Sacks, Steven H.
Lombardi, Giovanna
Zhou, Wuding
author_sort Li, Ke
collection PubMed
description Integration of innate and adaptive arms of the immune response at a cellular and molecular level appears to be fundamental to the development of powerful effector functions in host defence and aberrant immune responses. Here we provide evidence that the functions of human complement activation and antigen presentation converge on dendritic cells (DCs). We show that several subsets of human DCs [i.e., monocyte derived (CD1a(+)CD14(−)), dermal (CD1a(+)DC-SIGN(+)), Langerhans (CD1a(+)Langerin(+)), myeloid (CD1c(+)CD19(−)), plamacytoid (CD45RA(+)CD123(+))] express many of the components of the classical and alternative and terminal pathways of complement. Moreover human DCs have receptors known to detect the biologically active peptides C3a and C5a (C3aR, C5aR) and the covalently bound fragments C3b and metabolites iC3b and C3d which serve in immune adhesion (i.e., CR3, CR4, CRIg). We also show that the human DC surface is characterised by membrane bound regulators of complement activation, which are also known to participate in intracellular signalling (i.e., CD46, CD55, CD59). This work provides an extensive description of complement components relevant to the integrated actions of complement and DC, illuminated by animal studies. It acts as a resource that allows further understanding and exploitation of role of complement in human health and immune mediated diseases.
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spelling pubmed-30844452011-05-03 Expression of complement components, receptors and regulators by human dendritic cells Li, Ke Fazekasova, Henrieta Wang, Naiyin Sagoo, Pervinder Peng, Qi Khamri, Wafa Gomes, Chantelle Sacks, Steven H. Lombardi, Giovanna Zhou, Wuding Mol Immunol Article Integration of innate and adaptive arms of the immune response at a cellular and molecular level appears to be fundamental to the development of powerful effector functions in host defence and aberrant immune responses. Here we provide evidence that the functions of human complement activation and antigen presentation converge on dendritic cells (DCs). We show that several subsets of human DCs [i.e., monocyte derived (CD1a(+)CD14(−)), dermal (CD1a(+)DC-SIGN(+)), Langerhans (CD1a(+)Langerin(+)), myeloid (CD1c(+)CD19(−)), plamacytoid (CD45RA(+)CD123(+))] express many of the components of the classical and alternative and terminal pathways of complement. Moreover human DCs have receptors known to detect the biologically active peptides C3a and C5a (C3aR, C5aR) and the covalently bound fragments C3b and metabolites iC3b and C3d which serve in immune adhesion (i.e., CR3, CR4, CRIg). We also show that the human DC surface is characterised by membrane bound regulators of complement activation, which are also known to participate in intracellular signalling (i.e., CD46, CD55, CD59). This work provides an extensive description of complement components relevant to the integrated actions of complement and DC, illuminated by animal studies. It acts as a resource that allows further understanding and exploitation of role of complement in human health and immune mediated diseases. Pergamon Press 2011-05 /pmc/articles/PMC3084445/ /pubmed/21397947 http://dx.doi.org/10.1016/j.molimm.2011.02.003 Text en © 2011 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Li, Ke
Fazekasova, Henrieta
Wang, Naiyin
Sagoo, Pervinder
Peng, Qi
Khamri, Wafa
Gomes, Chantelle
Sacks, Steven H.
Lombardi, Giovanna
Zhou, Wuding
Expression of complement components, receptors and regulators by human dendritic cells
title Expression of complement components, receptors and regulators by human dendritic cells
title_full Expression of complement components, receptors and regulators by human dendritic cells
title_fullStr Expression of complement components, receptors and regulators by human dendritic cells
title_full_unstemmed Expression of complement components, receptors and regulators by human dendritic cells
title_short Expression of complement components, receptors and regulators by human dendritic cells
title_sort expression of complement components, receptors and regulators by human dendritic cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084445/
https://www.ncbi.nlm.nih.gov/pubmed/21397947
http://dx.doi.org/10.1016/j.molimm.2011.02.003
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