Cargando…
Hazardous Compounds in Tobacco Smoke
Tobacco smoke is a toxic and carcinogenic mixture of more than 5,000 chemicals. The present article provides a list of 98 hazardous smoke components, based on an extensive literature search for known smoke components and their human health inhalation risks. An electronic database of smoke components...
Autores principales: | , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084482/ https://www.ncbi.nlm.nih.gov/pubmed/21556207 http://dx.doi.org/10.3390/ijerph8020613 |
_version_ | 1782202511171518464 |
---|---|
author | Talhout, Reinskje Schulz, Thomas Florek, Ewa van Benthem, Jan Wester, Piet Opperhuizen, Antoon |
author_facet | Talhout, Reinskje Schulz, Thomas Florek, Ewa van Benthem, Jan Wester, Piet Opperhuizen, Antoon |
author_sort | Talhout, Reinskje |
collection | PubMed |
description | Tobacco smoke is a toxic and carcinogenic mixture of more than 5,000 chemicals. The present article provides a list of 98 hazardous smoke components, based on an extensive literature search for known smoke components and their human health inhalation risks. An electronic database of smoke components containing more than 2,200 entries was generated. Emission levels in mainstream smoke have been found for 542 of the components and a human inhalation risk value for 98 components. As components with potential carcinogenic, cardiovascular and respiratory effects have been included, the three major smoke-related causes of death are all covered by the list. Given that the currently used Hoffmann list of hazardous smoke components is based on data from the 1990s and only includes carcinogens, it is recommended that the current list of 98 hazardous components is used for regulatory purposes instead. To enable risk assessment of components not covered by this list, thresholds of toxicological concern (TTC) have been established from the inhalation risk values found: 0.0018 μg day(−1) for all risks, and 1.2 μg day(−1) for all risks excluding carcinogenicity, the latter being similar to previously reported inhalation TTCs. |
format | Text |
id | pubmed-3084482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-30844822011-05-09 Hazardous Compounds in Tobacco Smoke Talhout, Reinskje Schulz, Thomas Florek, Ewa van Benthem, Jan Wester, Piet Opperhuizen, Antoon Int J Environ Res Public Health Article Tobacco smoke is a toxic and carcinogenic mixture of more than 5,000 chemicals. The present article provides a list of 98 hazardous smoke components, based on an extensive literature search for known smoke components and their human health inhalation risks. An electronic database of smoke components containing more than 2,200 entries was generated. Emission levels in mainstream smoke have been found for 542 of the components and a human inhalation risk value for 98 components. As components with potential carcinogenic, cardiovascular and respiratory effects have been included, the three major smoke-related causes of death are all covered by the list. Given that the currently used Hoffmann list of hazardous smoke components is based on data from the 1990s and only includes carcinogens, it is recommended that the current list of 98 hazardous components is used for regulatory purposes instead. To enable risk assessment of components not covered by this list, thresholds of toxicological concern (TTC) have been established from the inhalation risk values found: 0.0018 μg day(−1) for all risks, and 1.2 μg day(−1) for all risks excluding carcinogenicity, the latter being similar to previously reported inhalation TTCs. Molecular Diversity Preservation International (MDPI) 2011-02 2011-02-23 /pmc/articles/PMC3084482/ /pubmed/21556207 http://dx.doi.org/10.3390/ijerph8020613 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Talhout, Reinskje Schulz, Thomas Florek, Ewa van Benthem, Jan Wester, Piet Opperhuizen, Antoon Hazardous Compounds in Tobacco Smoke |
title | Hazardous Compounds in Tobacco Smoke |
title_full | Hazardous Compounds in Tobacco Smoke |
title_fullStr | Hazardous Compounds in Tobacco Smoke |
title_full_unstemmed | Hazardous Compounds in Tobacco Smoke |
title_short | Hazardous Compounds in Tobacco Smoke |
title_sort | hazardous compounds in tobacco smoke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084482/ https://www.ncbi.nlm.nih.gov/pubmed/21556207 http://dx.doi.org/10.3390/ijerph8020613 |
work_keys_str_mv | AT talhoutreinskje hazardouscompoundsintobaccosmoke AT schulzthomas hazardouscompoundsintobaccosmoke AT florekewa hazardouscompoundsintobaccosmoke AT vanbenthemjan hazardouscompoundsintobaccosmoke AT westerpiet hazardouscompoundsintobaccosmoke AT opperhuizenantoon hazardouscompoundsintobaccosmoke |