Cargando…

The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task

Multiple memory systems are involved in parallel processing of spatial information during navigation. A series of studies have distinguished between hippocampus-dependent ‘spatial’ navigation, which relies on knowledge of the relationship between landmarks in one’s environment to build a cognitive m...

Descripción completa

Detalles Bibliográficos
Autores principales: Banner, Harrison, Bhat, Venkataramana, Etchamendy, Nicole, Joober, Ridha, Bohbot, Véronique D
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084505/
https://www.ncbi.nlm.nih.gov/pubmed/21255124
http://dx.doi.org/10.1111/j.1460-9568.2010.07550.x
_version_ 1782202514136891392
author Banner, Harrison
Bhat, Venkataramana
Etchamendy, Nicole
Joober, Ridha
Bohbot, Véronique D
author_facet Banner, Harrison
Bhat, Venkataramana
Etchamendy, Nicole
Joober, Ridha
Bohbot, Véronique D
author_sort Banner, Harrison
collection PubMed
description Multiple memory systems are involved in parallel processing of spatial information during navigation. A series of studies have distinguished between hippocampus-dependent ‘spatial’ navigation, which relies on knowledge of the relationship between landmarks in one’s environment to build a cognitive map, and habit-based ‘response’ learning, which requires the memorization of a series of actions and is mediated by the caudate nucleus. Studies have demonstrated that people spontaneously use one of these two alternative navigational strategies with almost equal frequency to solve a given navigation task, and that strategy correlates with functional magnetic resonance imaging (fMRI) activity and grey matter density. Although there is evidence for experience modulating grey matter in the hippocampus, genetic contributions may also play an important role in the hippocampus and caudate nucleus. Recently, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene has emerged as a possible inhibitor of hippocampal function. We have investigated the role of the BDNF Val66Met polymorphism on virtual navigation behaviour and brain activation during an fMRI navigation task. Our results demonstrate a genetic contribution to spontaneous strategies, where ‘Met’ carriers use a response strategy more frequently than individuals homozygous for the ‘Val’ allele. Additionally, we found increased hippocampal activation in the Val group relative to the Met group during performance of a virtual navigation task. Our results support the idea that the BDNF gene with the Val66Met polymorphism is a novel candidate gene involved in determining spontaneous strategies during navigation behaviour.
format Text
id pubmed-3084505
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-30845052011-05-11 The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task Banner, Harrison Bhat, Venkataramana Etchamendy, Nicole Joober, Ridha Bohbot, Véronique D Eur J Neurosci Cognitive Neuroscience Multiple memory systems are involved in parallel processing of spatial information during navigation. A series of studies have distinguished between hippocampus-dependent ‘spatial’ navigation, which relies on knowledge of the relationship between landmarks in one’s environment to build a cognitive map, and habit-based ‘response’ learning, which requires the memorization of a series of actions and is mediated by the caudate nucleus. Studies have demonstrated that people spontaneously use one of these two alternative navigational strategies with almost equal frequency to solve a given navigation task, and that strategy correlates with functional magnetic resonance imaging (fMRI) activity and grey matter density. Although there is evidence for experience modulating grey matter in the hippocampus, genetic contributions may also play an important role in the hippocampus and caudate nucleus. Recently, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene has emerged as a possible inhibitor of hippocampal function. We have investigated the role of the BDNF Val66Met polymorphism on virtual navigation behaviour and brain activation during an fMRI navigation task. Our results demonstrate a genetic contribution to spontaneous strategies, where ‘Met’ carriers use a response strategy more frequently than individuals homozygous for the ‘Val’ allele. Additionally, we found increased hippocampal activation in the Val group relative to the Met group during performance of a virtual navigation task. Our results support the idea that the BDNF gene with the Val66Met polymorphism is a novel candidate gene involved in determining spontaneous strategies during navigation behaviour. Blackwell Publishing Ltd 2011-03 /pmc/articles/PMC3084505/ /pubmed/21255124 http://dx.doi.org/10.1111/j.1460-9568.2010.07550.x Text en European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Cognitive Neuroscience
Banner, Harrison
Bhat, Venkataramana
Etchamendy, Nicole
Joober, Ridha
Bohbot, Véronique D
The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
title The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
title_full The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
title_fullStr The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
title_full_unstemmed The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
title_short The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
title_sort brain-derived neurotrophic factor val66met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
topic Cognitive Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084505/
https://www.ncbi.nlm.nih.gov/pubmed/21255124
http://dx.doi.org/10.1111/j.1460-9568.2010.07550.x
work_keys_str_mv AT bannerharrison thebrainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT bhatvenkataramana thebrainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT etchamendynicole thebrainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT jooberridha thebrainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT bohbotveroniqued thebrainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT bannerharrison brainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT bhatvenkataramana brainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT etchamendynicole brainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT jooberridha brainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask
AT bohbotveroniqued brainderivedneurotrophicfactorval66metpolymorphismisassociatedwithreducedfunctionalmagneticresonanceimagingactivityinthehippocampusandincreaseduseofcaudatenucleusdependentstrategiesinahumanvirtualnavigationtask