Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation

ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca(2+) [(Ca(2+))(o)]. Lowering [Ca(2+)](o) paradoxically enhances ADP-evoked aggregation, an effect that has been attributed to enhanced thromboxane...

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Detalles Bibliográficos
Autores principales: Jones, Sarah, Evans, Richard J, Mahaut-Smith, Martyn P
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Platelets, Haemostasis and Thrombosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084511/
https://www.ncbi.nlm.nih.gov/pubmed/21332705
http://dx.doi.org/10.1111/j.1365-2141.2010.08499.x

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