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Mek1/2 Gene Dosage Determines Tissue Response to Oncogenic Ras Signaling in the Skin

Ras genes are commonly mutated in human cancers of the skin and other tissues. Oncogenic Ras signals through multiple effector pathways, including the Erk1/2 MAPK, phosphatidylinositol-3 kinase (PI3K), and the Ral guanine nucleotide exchange factor (RalGEF) cascades. In epidermis, activation of onco...

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Detalles Bibliográficos
Autores principales:	Scholl, F A, Dumesic, P A, Barragan, D I, Charron, J, Khavari, P A
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084589/ https://www.ncbi.nlm.nih.gov/pubmed/19198628 http://dx.doi.org/10.1038/onc.2008.459

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