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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies (GWAS) and candidate gene studies in ulcerative colitis (UC) have identified 18 susceptibility loci. We conducted a meta-analysis of 6 UC GWAS, comprising 6,687 cases and 19,718 controls, and followed-up the top association signals in 9,628 cases and 12,917 controls....
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597/ https://www.ncbi.nlm.nih.gov/pubmed/21297633 http://dx.doi.org/10.1038/ng.764 |
| _version_ | 1782202523954708480 |
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| author | Anderson, Carl A. Boucher, Gabrielle Lees, Charlie W. Franke, Andre D’Amato, Mauro Taylor, Kent D. Lee, James C. Goyette, Philippe Imielinski, Marcin Latiano, Anna Lagacé, Caroline Scott, Regan Amininejad, Leila Bumpstead, Suzannah Baidoo, Leonard Baldassano, Robert N. Barclay, Murray Bayless, Theodore M. Brand, Stephan Büning, Carsten Colombel, Jean-Frédéric Denson, Lee A. De Vos, Martine Dubinsky, Marla Edwards, Cathryn Ellinghaus, David Fehrmann, Rudolf S.N. Floyd, James A.B. Florin, Tim Franchimont, Denis Franke, Lude Georges, Michel Glas, Jürgen Glazer, Nicole L. Guthery, Stephen L. Haritunians, Talin Hayward, Nicholas K. Hugot, Jean-Pierre Jobin, Gilles Laukens, Debby Lawrance, Ian Lémann, Marc Levine, Arie Libioulle, Cecile Louis, Edouard McGovern, Dermot P. Milla, Monica Montgomery, Grant W. Morley, Katherine I. Mowat, Craig Ng, Aylwin Newman, William Ophoff, Roel A Papi, Laura Palmieri, Orazio Peyrin-Biroulet, Laurent Panés, Julián Phillips, Anne Prescott, Natalie J. Proctor, Deborah D. Roberts, Rebecca Russell, Richard Rutgeerts, Paul Sanderson, Jeremy Sans, Miquel Schumm, Philip Seibold, Frank Sharma, Yashoda Simms, Lisa Seielstad, Mark Steinhart, A. Hillary Targan, Stephan R. van den Berg, Leonard H. Vatn, Morten Verspaget, Hein Walters, Thomas Wijmenga, Cisca Wilson, David C. Westra, Harm-Jan Xavier, Ramnik J. Zhao, Zhen Z. Ponsioen, Cyriel Y. Andersen, Vibeke Torkvist, Leif Gazouli, Maria Anagnou, Nicholas P. Karlsen, Tom H. Kupcinskas, Limas Sventoraityte, Jurgita Mansfield, John C. Kugathasan, Subra Silverberg, Mark S. Halfvarson, Jonas Rotter, Jerome I. Mathew, Christopher G. Griffiths, Anne M. Gearry, Richard Ahmad, Tariq Brant, Steven R. Chamaillard, Mathias Satsangi, Jack Cho, Judy H. Schreiber, Stefan Daly, Mark J. Barrett, Jeffrey C. Parkes, Miles Annese, Vito Hakonarson, Hakon Radford-Smith, Graham Duerr, Richard H. Vermeire, Séverine Weersma, Rinse K. Rioux, John D. |
| author_facet | Anderson, Carl A. Boucher, Gabrielle Lees, Charlie W. Franke, Andre D’Amato, Mauro Taylor, Kent D. Lee, James C. Goyette, Philippe Imielinski, Marcin Latiano, Anna Lagacé, Caroline Scott, Regan Amininejad, Leila Bumpstead, Suzannah Baidoo, Leonard Baldassano, Robert N. Barclay, Murray Bayless, Theodore M. Brand, Stephan Büning, Carsten Colombel, Jean-Frédéric Denson, Lee A. De Vos, Martine Dubinsky, Marla Edwards, Cathryn Ellinghaus, David Fehrmann, Rudolf S.N. Floyd, James A.B. Florin, Tim Franchimont, Denis Franke, Lude Georges, Michel Glas, Jürgen Glazer, Nicole L. Guthery, Stephen L. Haritunians, Talin Hayward, Nicholas K. Hugot, Jean-Pierre Jobin, Gilles Laukens, Debby Lawrance, Ian Lémann, Marc Levine, Arie Libioulle, Cecile Louis, Edouard McGovern, Dermot P. Milla, Monica Montgomery, Grant W. Morley, Katherine I. Mowat, Craig Ng, Aylwin Newman, William Ophoff, Roel A Papi, Laura Palmieri, Orazio Peyrin-Biroulet, Laurent Panés, Julián Phillips, Anne Prescott, Natalie J. Proctor, Deborah D. Roberts, Rebecca Russell, Richard Rutgeerts, Paul Sanderson, Jeremy Sans, Miquel Schumm, Philip Seibold, Frank Sharma, Yashoda Simms, Lisa Seielstad, Mark Steinhart, A. Hillary Targan, Stephan R. van den Berg, Leonard H. Vatn, Morten Verspaget, Hein Walters, Thomas Wijmenga, Cisca Wilson, David C. Westra, Harm-Jan Xavier, Ramnik J. Zhao, Zhen Z. Ponsioen, Cyriel Y. Andersen, Vibeke Torkvist, Leif Gazouli, Maria Anagnou, Nicholas P. Karlsen, Tom H. Kupcinskas, Limas Sventoraityte, Jurgita Mansfield, John C. Kugathasan, Subra Silverberg, Mark S. Halfvarson, Jonas Rotter, Jerome I. Mathew, Christopher G. Griffiths, Anne M. Gearry, Richard Ahmad, Tariq Brant, Steven R. Chamaillard, Mathias Satsangi, Jack Cho, Judy H. Schreiber, Stefan Daly, Mark J. Barrett, Jeffrey C. Parkes, Miles Annese, Vito Hakonarson, Hakon Radford-Smith, Graham Duerr, Richard H. Vermeire, Séverine Weersma, Rinse K. Rioux, John D. |
| author_sort | Anderson, Carl A. |
| collection | PubMed |
| description | Genome-wide association studies (GWAS) and candidate gene studies in ulcerative colitis (UC) have identified 18 susceptibility loci. We conducted a meta-analysis of 6 UC GWAS, comprising 6,687 cases and 19,718 controls, and followed-up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P<5×10(-8)), increasing the number of UC associated loci to 47. After annotating associated regions using GRAIL, eQTL data and correlations with non-synonymous SNPs, we identified many candidate genes providing potentially important insights into disease pathogenesis, including IL1R2, IL8RA/B, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease (IBD) risk loci is now 99, including a minimum of 28 shared association signals between Crohn’s disease (CD) and UC. |
| format | Text |
| id | pubmed-3084597 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30845972011-09-01 Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 Anderson, Carl A. Boucher, Gabrielle Lees, Charlie W. Franke, Andre D’Amato, Mauro Taylor, Kent D. Lee, James C. Goyette, Philippe Imielinski, Marcin Latiano, Anna Lagacé, Caroline Scott, Regan Amininejad, Leila Bumpstead, Suzannah Baidoo, Leonard Baldassano, Robert N. Barclay, Murray Bayless, Theodore M. Brand, Stephan Büning, Carsten Colombel, Jean-Frédéric Denson, Lee A. De Vos, Martine Dubinsky, Marla Edwards, Cathryn Ellinghaus, David Fehrmann, Rudolf S.N. Floyd, James A.B. Florin, Tim Franchimont, Denis Franke, Lude Georges, Michel Glas, Jürgen Glazer, Nicole L. Guthery, Stephen L. Haritunians, Talin Hayward, Nicholas K. Hugot, Jean-Pierre Jobin, Gilles Laukens, Debby Lawrance, Ian Lémann, Marc Levine, Arie Libioulle, Cecile Louis, Edouard McGovern, Dermot P. Milla, Monica Montgomery, Grant W. Morley, Katherine I. Mowat, Craig Ng, Aylwin Newman, William Ophoff, Roel A Papi, Laura Palmieri, Orazio Peyrin-Biroulet, Laurent Panés, Julián Phillips, Anne Prescott, Natalie J. Proctor, Deborah D. Roberts, Rebecca Russell, Richard Rutgeerts, Paul Sanderson, Jeremy Sans, Miquel Schumm, Philip Seibold, Frank Sharma, Yashoda Simms, Lisa Seielstad, Mark Steinhart, A. Hillary Targan, Stephan R. van den Berg, Leonard H. Vatn, Morten Verspaget, Hein Walters, Thomas Wijmenga, Cisca Wilson, David C. Westra, Harm-Jan Xavier, Ramnik J. Zhao, Zhen Z. Ponsioen, Cyriel Y. Andersen, Vibeke Torkvist, Leif Gazouli, Maria Anagnou, Nicholas P. Karlsen, Tom H. Kupcinskas, Limas Sventoraityte, Jurgita Mansfield, John C. Kugathasan, Subra Silverberg, Mark S. Halfvarson, Jonas Rotter, Jerome I. Mathew, Christopher G. Griffiths, Anne M. Gearry, Richard Ahmad, Tariq Brant, Steven R. Chamaillard, Mathias Satsangi, Jack Cho, Judy H. Schreiber, Stefan Daly, Mark J. Barrett, Jeffrey C. Parkes, Miles Annese, Vito Hakonarson, Hakon Radford-Smith, Graham Duerr, Richard H. Vermeire, Séverine Weersma, Rinse K. Rioux, John D. Nat Genet Article Genome-wide association studies (GWAS) and candidate gene studies in ulcerative colitis (UC) have identified 18 susceptibility loci. We conducted a meta-analysis of 6 UC GWAS, comprising 6,687 cases and 19,718 controls, and followed-up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P<5×10(-8)), increasing the number of UC associated loci to 47. After annotating associated regions using GRAIL, eQTL data and correlations with non-synonymous SNPs, we identified many candidate genes providing potentially important insights into disease pathogenesis, including IL1R2, IL8RA/B, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease (IBD) risk loci is now 99, including a minimum of 28 shared association signals between Crohn’s disease (CD) and UC. 2011-02-06 2011-03 /pmc/articles/PMC3084597/ /pubmed/21297633 http://dx.doi.org/10.1038/ng.764 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Anderson, Carl A. Boucher, Gabrielle Lees, Charlie W. Franke, Andre D’Amato, Mauro Taylor, Kent D. Lee, James C. Goyette, Philippe Imielinski, Marcin Latiano, Anna Lagacé, Caroline Scott, Regan Amininejad, Leila Bumpstead, Suzannah Baidoo, Leonard Baldassano, Robert N. Barclay, Murray Bayless, Theodore M. Brand, Stephan Büning, Carsten Colombel, Jean-Frédéric Denson, Lee A. De Vos, Martine Dubinsky, Marla Edwards, Cathryn Ellinghaus, David Fehrmann, Rudolf S.N. Floyd, James A.B. Florin, Tim Franchimont, Denis Franke, Lude Georges, Michel Glas, Jürgen Glazer, Nicole L. Guthery, Stephen L. Haritunians, Talin Hayward, Nicholas K. Hugot, Jean-Pierre Jobin, Gilles Laukens, Debby Lawrance, Ian Lémann, Marc Levine, Arie Libioulle, Cecile Louis, Edouard McGovern, Dermot P. Milla, Monica Montgomery, Grant W. Morley, Katherine I. Mowat, Craig Ng, Aylwin Newman, William Ophoff, Roel A Papi, Laura Palmieri, Orazio Peyrin-Biroulet, Laurent Panés, Julián Phillips, Anne Prescott, Natalie J. Proctor, Deborah D. Roberts, Rebecca Russell, Richard Rutgeerts, Paul Sanderson, Jeremy Sans, Miquel Schumm, Philip Seibold, Frank Sharma, Yashoda Simms, Lisa Seielstad, Mark Steinhart, A. Hillary Targan, Stephan R. van den Berg, Leonard H. Vatn, Morten Verspaget, Hein Walters, Thomas Wijmenga, Cisca Wilson, David C. Westra, Harm-Jan Xavier, Ramnik J. Zhao, Zhen Z. Ponsioen, Cyriel Y. Andersen, Vibeke Torkvist, Leif Gazouli, Maria Anagnou, Nicholas P. Karlsen, Tom H. Kupcinskas, Limas Sventoraityte, Jurgita Mansfield, John C. Kugathasan, Subra Silverberg, Mark S. Halfvarson, Jonas Rotter, Jerome I. Mathew, Christopher G. Griffiths, Anne M. Gearry, Richard Ahmad, Tariq Brant, Steven R. Chamaillard, Mathias Satsangi, Jack Cho, Judy H. Schreiber, Stefan Daly, Mark J. Barrett, Jeffrey C. Parkes, Miles Annese, Vito Hakonarson, Hakon Radford-Smith, Graham Duerr, Richard H. Vermeire, Séverine Weersma, Rinse K. Rioux, John D. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| title | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| title_full | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| title_fullStr | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| title_full_unstemmed | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| title_short | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| title_sort | meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597/ https://www.ncbi.nlm.nih.gov/pubmed/21297633 http://dx.doi.org/10.1038/ng.764 |
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