Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

PURPOSE: The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy. METHODS: CNV lesion...

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Detalles Bibliográficos
Autores principales: Salehi-Had, Hani, Roh, Mi In, Giani, Andrea, Hisatomi, Toshio, Nakao, Shintaro, Kim, Ivana K., Gragoudas, Evangelos S., Vavvas, Demetrios, Guccione, Samira, Miller, Joan W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084713/
https://www.ncbi.nlm.nih.gov/pubmed/21559527
http://dx.doi.org/10.1371/journal.pone.0018864

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