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Resistance of Renal Cell Carcinoma to Sorafenib Is Mediated by Potentially Reversible Gene Expression

PURPOSE: Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic changes in resistant tumor cells. EXPERIMENTAL DESIGN: Mice bearing two human...

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Detalles Bibliográficos
Autores principales:	Zhang, Liang, Bhasin, Manoj, Schor-Bardach, Rachel, Wang, Xiaoen, Collins, Michael P., Panka, David, Putheti, Prabhakar, Signoretti, Sabina, Alsop, David C., Libermann, Towia, Atkins, Michael B., Mier, James W., Goldberg, S. Nahum, Bhatt, Rupal S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084751/ https://www.ncbi.nlm.nih.gov/pubmed/21559452 http://dx.doi.org/10.1371/journal.pone.0019144

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