Cargando…

Amplification of the Angiogenic Signal through the Activation of the TSC/mTOR/HIF Axis by the KSHV vGPCR in Kaposi's Sarcoma

BACKGROUND: Kaposi's sarcoma (KS) is a vascular neoplasm characterized by the dysregulated expression of angiogenic and inflammatory cytokines. The driving force of the KS lesion, the KSHV-infected spindle cell, secretes elevated levels of vascular endothelial growth factor (VEGF), essential fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jham, Bruno C., Ma, Tao, Hu, Jiadi, Chaisuparat, Risa, Friedman, Eitan R., Pandolfi, Pier Paolo, Schneider, Abraham, Sodhi, Akrit, Montaner, Silvia
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084756/ https://www.ncbi.nlm.nih.gov/pubmed/21559457 http://dx.doi.org/10.1371/journal.pone.0019103

Ejemplares similares

AKT/TSC/mTOR activation by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor: novel therapeutic targets for the treatment of Kaposi's sarcoma
por: Montaner, S, et al.
Publicado: (2009)

Glycosylation of KSHV Encoded vGPCR Functions in Its Signaling and Tumorigenicity
por: Wu, Hui, et al.
Publicado: (2015)

Upregulation of angiopoietin-like 4 by viral G protein-coupled receptor promotes angiogenesis and vascular permeability in Kaposi’s sarcoma
por: Ma, Tao, et al.
Publicado: (2010)

KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi’s sarcoma
por: Medina, María Victoria, et al.
Publicado: (2020)

CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation
por: Hunte, Richard, et al.
Publicado: (2018)

MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR
por: Krause, Claudia J., et al.
Publicado: (2016)

The HHV-8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells
por: Lira, Sergio A
Publicado: (2006)

The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity
por: Dwyer, Julie, et al.
Publicado: (2015)

Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28
por: Frank, Theresa, et al.
Publicado: (2016)

PDGFRA defines the mesenchymal stem cell Kaposi’s sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment
por: Naipauer, Julian, et al.
Publicado: (2019)

KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes
por: DiMaio, Terri A., et al.
Publicado: (2012)

KSHV regulation of fibulins in Kaposi’s sarcoma: implications for tumorigenesis
por: Alcendor, Donald, et al.
Publicado: (2010)

PAI-1 is a vascular cell–specific HIF-2–dependent angiogenic factor that promotes retinal neovascularization in diabetic patients
por: Qin, Yaowu, et al.
Publicado: (2022)

Review of the distribution of Kaposi's sarcoma-associated herpesvirus (KSHV) in Africa in relation to the incidence of Kaposi's sarcoma
por: Dedicoat, M, et al.
Publicado: (2003)

KSHV/HHV-8 and HIV infection in Kaposi's sarcoma development
por: Pyakurel, Pawan, et al.
Publicado: (2007)

Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy
por: Jee, Kathleen, et al.
Publicado: (2017)

Transient induction of lytic Kaposi's sarcoma-associated herpesvirus (KSHV) genes in KSHV-infected endothelial cells exposed to hypoxia
por: Velasco, P, et al.
Publicado: (2009)

Efficient lytic induction of kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines
por: Kang, Hyunju, et al.
Publicado: (2014)

Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy
por: Rodrigues, Murilo, et al.
Publicado: (2016)

Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV–MCD) and the KSHV Inflammatory Cytokine Syndrome
por: Polizzotto, Mark N., et al.
Publicado: (2012)

Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women
por: Wakeham, Katie, et al.
Publicado: (2011)

KSHV-mediated ROS induction defines novel therapeutic targets in Kaposi’s sarcoma
por: Cavallin, Lucas E, et al.
Publicado: (2010)

Molecular and Cellular Mechanisms of KSHV Oncogenesis of Kaposi's Sarcoma Associated with HIV/AIDS
por: Cavallin, Lucas E., et al.
Publicado: (2014)

Next-Generation Sequencing in the Understanding of Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Biology
por: Strahan, Roxanne, et al.
Publicado: (2016)

Corrigendum: Clinical manifestations of Kaposi sarcoma herpesvirus lytic activation: multicentric Castleman disease (KSHV–MCD) and the KSHV inflammatory cytokine syndrome
por: Polizzotto, Mark N., et al.
Publicado: (2017)

The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals
por: Mortazavi, Yasaman, et al.
Publicado: (2020)

Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia
por: Meng, Qianli, et al.
Publicado: (2017)

Post-Translational Modifications of Kaposi’s Sarcoma-Associated Herpesvirus Regulatory Proteins – SUMO and KSHV
por: Campbell, Mel, et al.
Publicado: (2012)

Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in South Africa
por: Malope-Kgokong, Babatyi I, et al.
Publicado: (2010)

Suppression of galectin-3 in KSHV infected DMVEC cells and Kaposi's sarcoma: implications for tumorigenesis
por: Alcendor, DJ, et al.
Publicado: (2009)

KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis
por: Cavallin, Lucas E., et al.
Publicado: (2018)

Lytic Reactivation of the Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Is Accompanied by Major Nucleolar Alterations
por: Atari, Nofar, et al.
Publicado: (2022)

Upregulation of Cell Surface Glycoproteins in Correlation with KSHV LANA in the Kaposi Sarcoma Tumor Microenvironment
por: Privatt, Sara R., et al.
Publicado: (2023)

Infection with Kaposi's sarcoma-associated herpesvirus (KSHV) and human immunodeficiency virus (HIV) in relation to the risk and clinical presentation of Kaposi's sarcoma in Uganda
por: Newton, R, et al.
Publicado: (2003)

Kaposi sarcoma herpesvirus (KSHV)-associated lymphomas are associated with markedly elevated serum IL-10, elevated IL-6, IL-17 and circulating KSHV
por: Uldrick, Thomas S, et al.
Publicado: (2012)

Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi’s Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells
por: Simpson, Sydney, et al.
Publicado: (2018)

Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s Sarcoma development
por: Dai, Lu, et al.
Publicado: (2018)

Disrupting Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor
por: Berwanger, Aylin, et al.
Publicado: (2023)

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein
por: Bussey, Kendra A., et al.
Publicado: (2018)

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma
por: Hu, Ke, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nh5jk1ki8a57c3gc1vqemh4jnv