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A Guide to Delineate the Logic of Neurovascular Signaling in the Brain
The neurovascular system may be viewed as a distributed nervous system within the brain. It transforms local neuronal activity into a change in the tone of smooth muscle that lines the walls of arterioles and microvessels. We review the current state of neurovascular coupling, with an emphasis on si...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085135/ https://www.ncbi.nlm.nih.gov/pubmed/21559095 http://dx.doi.org/10.3389/fnene.2011.00001 |
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author | Kleinfeld, David Blinder, Pablo Drew, Patrick J. Driscoll, Jonathan D. Muller, Arnaud Tsai, Philbert S. Shih, Andy Y. |
author_facet | Kleinfeld, David Blinder, Pablo Drew, Patrick J. Driscoll, Jonathan D. Muller, Arnaud Tsai, Philbert S. Shih, Andy Y. |
author_sort | Kleinfeld, David |
collection | PubMed |
description | The neurovascular system may be viewed as a distributed nervous system within the brain. It transforms local neuronal activity into a change in the tone of smooth muscle that lines the walls of arterioles and microvessels. We review the current state of neurovascular coupling, with an emphasis on signaling molecules that convey information from neurons to neighboring vessels. At the level of neocortex, this coupling is mediated by: (i) a likely direct interaction with inhibitory neurons, (ii) indirect interaction, via astrocytes, with excitatory neurons, and (iii) fiber tracts from subcortical layers. Substantial evidence shows that control involves competition between signals that promote vasoconstriction versus vasodilation. Consistent with this picture is evidence that, under certain circumstances, increased neuronal activity can lead to vasoconstriction rather than vasodilation. This confounds naïve interpretations of functional brain images. We discuss experimental approaches to detect signaling molecules in vivo with the goal of formulating an empirical basis for the observed logic of neurovascular control. |
format | Text |
id | pubmed-3085135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30851352011-05-10 A Guide to Delineate the Logic of Neurovascular Signaling in the Brain Kleinfeld, David Blinder, Pablo Drew, Patrick J. Driscoll, Jonathan D. Muller, Arnaud Tsai, Philbert S. Shih, Andy Y. Front Neuroenergetics Neuroscience The neurovascular system may be viewed as a distributed nervous system within the brain. It transforms local neuronal activity into a change in the tone of smooth muscle that lines the walls of arterioles and microvessels. We review the current state of neurovascular coupling, with an emphasis on signaling molecules that convey information from neurons to neighboring vessels. At the level of neocortex, this coupling is mediated by: (i) a likely direct interaction with inhibitory neurons, (ii) indirect interaction, via astrocytes, with excitatory neurons, and (iii) fiber tracts from subcortical layers. Substantial evidence shows that control involves competition between signals that promote vasoconstriction versus vasodilation. Consistent with this picture is evidence that, under certain circumstances, increased neuronal activity can lead to vasoconstriction rather than vasodilation. This confounds naïve interpretations of functional brain images. We discuss experimental approaches to detect signaling molecules in vivo with the goal of formulating an empirical basis for the observed logic of neurovascular control. Frontiers Research Foundation 2011-04-25 /pmc/articles/PMC3085135/ /pubmed/21559095 http://dx.doi.org/10.3389/fnene.2011.00001 Text en Copyright © 2011 Kleinfeld, Blinder, Drew, Driscoll, Muller, Tsai and Shih. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Neuroscience Kleinfeld, David Blinder, Pablo Drew, Patrick J. Driscoll, Jonathan D. Muller, Arnaud Tsai, Philbert S. Shih, Andy Y. A Guide to Delineate the Logic of Neurovascular Signaling in the Brain |
title | A Guide to Delineate the Logic of Neurovascular Signaling in the Brain |
title_full | A Guide to Delineate the Logic of Neurovascular Signaling in the Brain |
title_fullStr | A Guide to Delineate the Logic of Neurovascular Signaling in the Brain |
title_full_unstemmed | A Guide to Delineate the Logic of Neurovascular Signaling in the Brain |
title_short | A Guide to Delineate the Logic of Neurovascular Signaling in the Brain |
title_sort | guide to delineate the logic of neurovascular signaling in the brain |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085135/ https://www.ncbi.nlm.nih.gov/pubmed/21559095 http://dx.doi.org/10.3389/fnene.2011.00001 |
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