Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital

A total of 39 non-duplicate isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter species isolated from blood and endotracheal secretions were tested for metallo-β-lactamase (MBL) production by modified-EDTA disc synergy and double disc synergy tests. The prevalence of MBLs was 3...

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Autores principales: De, Anuradha S., Kumar, Simit H., Baveja, Sujata M.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085226/
https://www.ncbi.nlm.nih.gov/pubmed/21572756
http://dx.doi.org/10.4103/0972-5229.76089
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author De, Anuradha S.
Kumar, Simit H.
Baveja, Sujata M.
author_facet De, Anuradha S.
Kumar, Simit H.
Baveja, Sujata M.
author_sort De, Anuradha S.
collection PubMed
description A total of 39 non-duplicate isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter species isolated from blood and endotracheal secretions were tested for metallo-β-lactamase (MBL) production by modified-EDTA disc synergy and double disc synergy tests. The prevalence of MBLs was 33.33% by both the above tests. All patients with MBL-positive isolates were multidrug resistant and had multiple risk factors like > 8 days hospital stay, catheterization, IV lines, previous antibiotic use, etc. These were risk factors for imipenem resistance also. The overall mortality in MBL-positive patients was 46.15%.
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spelling pubmed-30852262011-05-13 Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital De, Anuradha S. Kumar, Simit H. Baveja, Sujata M. Indian J Crit Care Med Short Communication A total of 39 non-duplicate isolates of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter species isolated from blood and endotracheal secretions were tested for metallo-β-lactamase (MBL) production by modified-EDTA disc synergy and double disc synergy tests. The prevalence of MBLs was 33.33% by both the above tests. All patients with MBL-positive isolates were multidrug resistant and had multiple risk factors like > 8 days hospital stay, catheterization, IV lines, previous antibiotic use, etc. These were risk factors for imipenem resistance also. The overall mortality in MBL-positive patients was 46.15%. Medknow Publications 2010 /pmc/articles/PMC3085226/ /pubmed/21572756 http://dx.doi.org/10.4103/0972-5229.76089 Text en © Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
De, Anuradha S.
Kumar, Simit H.
Baveja, Sujata M.
Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital
title Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital
title_full Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital
title_fullStr Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital
title_full_unstemmed Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital
title_short Prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas in a tertiary care hospital
title_sort prevalence of metallo-β-lactamase producing pseudomonas aeruginosa and acinetobacter species in intensive care areas in a tertiary care hospital
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085226/
https://www.ncbi.nlm.nih.gov/pubmed/21572756
http://dx.doi.org/10.4103/0972-5229.76089
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