What is Next for the Genetics of Multiple Sclerosis?

We review here our current understanding of the genetic aetiology of the common complex neurological disease multiple sclerosis (MS). The strongest genetic risk factor for MS is the major histocompatibility complex which was identified in the 1970s. In 2011, after a number of genome-wide association...

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Detalles Bibliográficos
Autores principales: Ramagopalan, Sreeram V., Dyment, David A.
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085300/
https://www.ncbi.nlm.nih.gov/pubmed/21541245
http://dx.doi.org/10.4061/2011/519450
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author Ramagopalan, Sreeram V.
Dyment, David A.
author_facet Ramagopalan, Sreeram V.
Dyment, David A.
author_sort Ramagopalan, Sreeram V.
collection PubMed
description We review here our current understanding of the genetic aetiology of the common complex neurological disease multiple sclerosis (MS). The strongest genetic risk factor for MS is the major histocompatibility complex which was identified in the 1970s. In 2011, after a number of genome-wide association studies have been completed and have identified approximately 20 new genes for MS, we ask the question—what is next for the genetics of MS?
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spelling pubmed-30853002011-05-03 What is Next for the Genetics of Multiple Sclerosis? Ramagopalan, Sreeram V. Dyment, David A. Autoimmune Dis Research Article We review here our current understanding of the genetic aetiology of the common complex neurological disease multiple sclerosis (MS). The strongest genetic risk factor for MS is the major histocompatibility complex which was identified in the 1970s. In 2011, after a number of genome-wide association studies have been completed and have identified approximately 20 new genes for MS, we ask the question—what is next for the genetics of MS? SAGE-Hindawi Access to Research 2011-03-28 /pmc/articles/PMC3085300/ /pubmed/21541245 http://dx.doi.org/10.4061/2011/519450 Text en Copyright © 2011 S. V. Ramagopalan and D. A. Dyment. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ramagopalan, Sreeram V.
Dyment, David A.
What is Next for the Genetics of Multiple Sclerosis?
title What is Next for the Genetics of Multiple Sclerosis?
title_full What is Next for the Genetics of Multiple Sclerosis?
title_fullStr What is Next for the Genetics of Multiple Sclerosis?
title_full_unstemmed What is Next for the Genetics of Multiple Sclerosis?
title_short What is Next for the Genetics of Multiple Sclerosis?
title_sort what is next for the genetics of multiple sclerosis?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085300/
https://www.ncbi.nlm.nih.gov/pubmed/21541245
http://dx.doi.org/10.4061/2011/519450
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AT dymentdavida whatisnextforthegeneticsofmultiplesclerosis

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