Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo

In both human and mouse it has been recently realized that natural killer (NK) cells do not emerge from the bone marrow with full functional competence but rather acquire functions in interaction with antigen-presenting cells (APCs), primarily dendritic cells (DCs). Here we review the mechanisms and...

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Detalles Bibliográficos
Autores principales: Chijioke, Obinna, Münz, Christian
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085306/
https://www.ncbi.nlm.nih.gov/pubmed/21541250
http://dx.doi.org/10.1155/2011/251679
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author Chijioke, Obinna
Münz, Christian
author_facet Chijioke, Obinna
Münz, Christian
author_sort Chijioke, Obinna
collection PubMed
description In both human and mouse it has been recently realized that natural killer (NK) cells do not emerge from the bone marrow with full functional competence but rather acquire functions in interaction with antigen-presenting cells (APCs), primarily dendritic cells (DCs). Here we review the mechanisms and the consequences of this NK-cell preactivation, as well as discuss new experimental models that now allow investigating these interactions for human NK cells and their response to human pathogens in vivo. These investigations will allow harnessing NK cells during vaccination for improved innate and adaptive immunity.
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spelling pubmed-30853062011-05-03 Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo Chijioke, Obinna Münz, Christian J Biomed Biotechnol Review Article In both human and mouse it has been recently realized that natural killer (NK) cells do not emerge from the bone marrow with full functional competence but rather acquire functions in interaction with antigen-presenting cells (APCs), primarily dendritic cells (DCs). Here we review the mechanisms and the consequences of this NK-cell preactivation, as well as discuss new experimental models that now allow investigating these interactions for human NK cells and their response to human pathogens in vivo. These investigations will allow harnessing NK cells during vaccination for improved innate and adaptive immunity. Hindawi Publishing Corporation 2011 2011-03-31 /pmc/articles/PMC3085306/ /pubmed/21541250 http://dx.doi.org/10.1155/2011/251679 Text en Copyright © 2011 O. Chijioke and C. Münz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chijioke, Obinna
Münz, Christian
Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo
title Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo
title_full Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo
title_fullStr Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo
title_full_unstemmed Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo
title_short Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo
title_sort interactions of human myeloid cells with natural killer cell subsets in vitro and in vivo
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085306/
https://www.ncbi.nlm.nih.gov/pubmed/21541250
http://dx.doi.org/10.1155/2011/251679
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AT munzchristian interactionsofhumanmyeloidcellswithnaturalkillercellsubsetsinvitroandinvivo

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