Cargando…

Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings

Our objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia. Methods. In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-supp...

Descripción completa

Detalles Bibliográficos
Autores principales: Castelnuovo, Barbara, Sempa, Joseph, Agnes, Kiragga N., Kamya, Moses R., Manabe, Yukari C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085383/
https://www.ncbi.nlm.nih.gov/pubmed/21541225
http://dx.doi.org/10.1155/2011/736938
_version_ 1782202629847252992
author Castelnuovo, Barbara
Sempa, Joseph
Agnes, Kiragga N.
Kamya, Moses R.
Manabe, Yukari C.
author_facet Castelnuovo, Barbara
Sempa, Joseph
Agnes, Kiragga N.
Kamya, Moses R.
Manabe, Yukari C.
author_sort Castelnuovo, Barbara
collection PubMed
description Our objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia. Methods. In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-suppression: (VL ≤1,000 copies/mL) (2) VL 1,001–10,000, or (3) VL >10,000. Results. Fifty-Three (11.2%) and 84 (17.8%) patients had a first episode of intermediate and high viremia, respectively. Patients with sustained suppression had better CD4+ T cell count increases over time compared to viremic patients (P < .001). The majority of patients with viremia achieved viral suppression when the measurement was repeated. Only 39.6% of patients with intermediate and 19.1% with high viremia eventually needed to be switched to second line (P = .008). Conclusions. The use of at least one repeat measurement rather than a single VL measurement could avert from 60% to 80% of unnecessary switches.
format Text
id pubmed-3085383
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-30853832011-05-03 Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings Castelnuovo, Barbara Sempa, Joseph Agnes, Kiragga N. Kamya, Moses R. Manabe, Yukari C. AIDS Res Treat Research Article Our objective was to evaluate outcomes in patients with sustained viral suppression compared to those with episodes of viremia. Methods. In a prospective cohort of patients started on ART in Uganda and followed for 48 months, patients were categorized according to viral load (VL): (1) sustained-suppression: (VL ≤1,000 copies/mL) (2) VL 1,001–10,000, or (3) VL >10,000. Results. Fifty-Three (11.2%) and 84 (17.8%) patients had a first episode of intermediate and high viremia, respectively. Patients with sustained suppression had better CD4+ T cell count increases over time compared to viremic patients (P < .001). The majority of patients with viremia achieved viral suppression when the measurement was repeated. Only 39.6% of patients with intermediate and 19.1% with high viremia eventually needed to be switched to second line (P = .008). Conclusions. The use of at least one repeat measurement rather than a single VL measurement could avert from 60% to 80% of unnecessary switches. Hindawi Publishing Corporation 2011 2011-04-10 /pmc/articles/PMC3085383/ /pubmed/21541225 http://dx.doi.org/10.1155/2011/736938 Text en Copyright © 2011 Barbara Castelnuovo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Castelnuovo, Barbara
Sempa, Joseph
Agnes, Kiragga N.
Kamya, Moses R.
Manabe, Yukari C.
Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
title Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
title_full Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
title_fullStr Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
title_full_unstemmed Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
title_short Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
title_sort evaluation of who criteria for viral failure in patients on antiretroviral treatment in resource-limited settings
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085383/
https://www.ncbi.nlm.nih.gov/pubmed/21541225
http://dx.doi.org/10.1155/2011/736938
work_keys_str_mv AT castelnuovobarbara evaluationofwhocriteriaforviralfailureinpatientsonantiretroviraltreatmentinresourcelimitedsettings
AT sempajoseph evaluationofwhocriteriaforviralfailureinpatientsonantiretroviraltreatmentinresourcelimitedsettings
AT agneskiraggan evaluationofwhocriteriaforviralfailureinpatientsonantiretroviraltreatmentinresourcelimitedsettings
AT kamyamosesr evaluationofwhocriteriaforviralfailureinpatientsonantiretroviraltreatmentinresourcelimitedsettings
AT manabeyukaric evaluationofwhocriteriaforviralfailureinpatientsonantiretroviraltreatmentinresourcelimitedsettings