Urinary Elimination of Coproporphyrins Is Dependent on ABCC2 Polymorphisms and Represents a Potential Biomarker of MRP2 Activity in Humans

MRP2 encoded by ABCC2 gene is involved in the secretion of numerous drugs and endogenous substrates. Patients with Dubin-Johnson syndrome due to mutation in ABCC2 gene have elevated urinary coproporphyrin ratio (UCP I/(I + III)). Here we investigated whether this ratio could serve as a biomarker of...

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Detalles Bibliográficos
Autores principales: Benz-de Bretagne, Isabelle, Respaud, Renaud, Vourc'h, Patrick, Halimi, Jean-Michel, Caille, Agnès, Hulot, Jean-Sébastien, Andres, Christian R., Le Guellec, Chantal
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085472/
https://www.ncbi.nlm.nih.gov/pubmed/21541183
http://dx.doi.org/10.1155/2011/498757

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