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Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies

Decreased level of high density-lipoprotein cholesterol (HDL-C) is a rigorous predictor for future cardiovascular events. Much effort is being made to develop HDL-C–raising pharmacotherapies in the attempt to avert the pandemic of atherosclerotic disease. Important properties by which HDL-C–raising...

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Detalles Bibliográficos
Autores principales: Duivenvoorden, Raphaël, Fayad, Zahi A.
Formato: Texto
Lenguaje:English
Publicado: Current Science Inc. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085734/
https://www.ncbi.nlm.nih.gov/pubmed/21465111
http://dx.doi.org/10.1007/s11883-011-0176-1
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author Duivenvoorden, Raphaël
Fayad, Zahi A.
author_facet Duivenvoorden, Raphaël
Fayad, Zahi A.
author_sort Duivenvoorden, Raphaël
collection PubMed
description Decreased level of high density-lipoprotein cholesterol (HDL-C) is a rigorous predictor for future cardiovascular events. Much effort is being made to develop HDL-C–raising pharmacotherapies in the attempt to avert the pandemic of atherosclerotic disease. Important properties by which HDL-C–raising compounds are effective involve improvement of cholesterol uptake from macrophages in plaque for transport back to the liver, improvement of endothelial function, and anti-inflammatory effects. Vascular imaging can aid in the determination which HDL-C–raising compounds are effective. Ultrasound and MRI have proved suitable for assessment of structural changes of the vessel wall. Ultrasound can also be used or assessment of endothelial function. 18F-fluordeoxyglucose positron emission tomography has opened up the possibility to assess vessel wall inflammation. In this article we discuss these various imaging techniques and how they can assess efficacy as well as provide pathophysiologic information on the mechanism of action of novel HDL-C–raising drugs.
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spelling pubmed-30857342011-06-06 Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies Duivenvoorden, Raphaël Fayad, Zahi A. Curr Atheroscler Rep Article Decreased level of high density-lipoprotein cholesterol (HDL-C) is a rigorous predictor for future cardiovascular events. Much effort is being made to develop HDL-C–raising pharmacotherapies in the attempt to avert the pandemic of atherosclerotic disease. Important properties by which HDL-C–raising compounds are effective involve improvement of cholesterol uptake from macrophages in plaque for transport back to the liver, improvement of endothelial function, and anti-inflammatory effects. Vascular imaging can aid in the determination which HDL-C–raising compounds are effective. Ultrasound and MRI have proved suitable for assessment of structural changes of the vessel wall. Ultrasound can also be used or assessment of endothelial function. 18F-fluordeoxyglucose positron emission tomography has opened up the possibility to assess vessel wall inflammation. In this article we discuss these various imaging techniques and how they can assess efficacy as well as provide pathophysiologic information on the mechanism of action of novel HDL-C–raising drugs. Current Science Inc. 2011-04-05 2011 /pmc/articles/PMC3085734/ /pubmed/21465111 http://dx.doi.org/10.1007/s11883-011-0176-1 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Duivenvoorden, Raphaël
Fayad, Zahi A.
Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies
title Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies
title_full Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies
title_fullStr Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies
title_full_unstemmed Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies
title_short Utility of Atherosclerosis Imaging in the Evaluation of High-Density Lipoprotein–Raising Therapies
title_sort utility of atherosclerosis imaging in the evaluation of high-density lipoprotein–raising therapies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085734/
https://www.ncbi.nlm.nih.gov/pubmed/21465111
http://dx.doi.org/10.1007/s11883-011-0176-1
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