Small voltage changes at nerve terminals travel up axons to affect action potential initiation

Nerve terminals are generally considered the destination points for electrical signals, which propagate unidirectionally from the soma to nerve terminals. Here, we demonstrate that small hyperpolarizations or depolarizations (~10 mV), generated under physiological conditions in rat nerve terminals,...

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Detalles Bibliográficos
Autores principales: Paradiso, Kenneth, Wu, Ling-Gang
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086371/
https://www.ncbi.nlm.nih.gov/pubmed/19349974
http://dx.doi.org/10.1038/nn.2301
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author Paradiso, Kenneth
Wu, Ling-Gang
author_facet Paradiso, Kenneth
Wu, Ling-Gang
author_sort Paradiso, Kenneth
collection PubMed
description Nerve terminals are generally considered the destination points for electrical signals, which propagate unidirectionally from the soma to nerve terminals. Here, we demonstrate that small hyperpolarizations or depolarizations (~10 mV), generated under physiological conditions in rat nerve terminals, backpropagate up the axon (~400 – 800 µm), and change the threshold for initiating action potentials and thus firing patterns. These results suggest a novel mechanism for information processing in neurons and neuronal circuits.
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spelling pubmed-30863712011-05-03 Small voltage changes at nerve terminals travel up axons to affect action potential initiation Paradiso, Kenneth Wu, Ling-Gang Nat Neurosci Article Nerve terminals are generally considered the destination points for electrical signals, which propagate unidirectionally from the soma to nerve terminals. Here, we demonstrate that small hyperpolarizations or depolarizations (~10 mV), generated under physiological conditions in rat nerve terminals, backpropagate up the axon (~400 – 800 µm), and change the threshold for initiating action potentials and thus firing patterns. These results suggest a novel mechanism for information processing in neurons and neuronal circuits. 2009-04-06 2009-05 /pmc/articles/PMC3086371/ /pubmed/19349974 http://dx.doi.org/10.1038/nn.2301 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Paradiso, Kenneth
Wu, Ling-Gang
Small voltage changes at nerve terminals travel up axons to affect action potential initiation
title Small voltage changes at nerve terminals travel up axons to affect action potential initiation
title_full Small voltage changes at nerve terminals travel up axons to affect action potential initiation
title_fullStr Small voltage changes at nerve terminals travel up axons to affect action potential initiation
title_full_unstemmed Small voltage changes at nerve terminals travel up axons to affect action potential initiation
title_short Small voltage changes at nerve terminals travel up axons to affect action potential initiation
title_sort small voltage changes at nerve terminals travel up axons to affect action potential initiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086371/
https://www.ncbi.nlm.nih.gov/pubmed/19349974
http://dx.doi.org/10.1038/nn.2301
work_keys_str_mv AT paradisokenneth smallvoltagechangesatnerveterminalstravelupaxonstoaffectactionpotentialinitiation
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