Generating a Wnt switch: it’s all about the right dosage

Wnt proteins can activate different branches of the Wnt signaling pathway, raising the question of specificity. In this issue, Nalesso et al. (2011. J. Cell Biol. doi:10.1083/jcb.201011051) provide an answer to this conundrum by showing that different concentrations of Wnt ligands can elicit differe...

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Detalles Bibliográficos
Autores principales: Kestler, Hans A., Kühl, Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087014/
https://www.ncbi.nlm.nih.gov/pubmed/21536746
http://dx.doi.org/10.1083/jcb.201103167
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author Kestler, Hans A.
Kühl, Michael
author_facet Kestler, Hans A.
Kühl, Michael
author_sort Kestler, Hans A.
collection PubMed
description Wnt proteins can activate different branches of the Wnt signaling pathway, raising the question of specificity. In this issue, Nalesso et al. (2011. J. Cell Biol. doi:10.1083/jcb.201011051) provide an answer to this conundrum by showing that different concentrations of Wnt ligands can elicit different intracellular responses. These findings not only provide new insights into the molecular mechanisms underlying Wnt signaling, but also indicate how Wnt gradients might contribute to tissue patterning during embryogenesis.
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spelling pubmed-30870142011-11-02 Generating a Wnt switch: it’s all about the right dosage Kestler, Hans A. Kühl, Michael J Cell Biol Reviews Wnt proteins can activate different branches of the Wnt signaling pathway, raising the question of specificity. In this issue, Nalesso et al. (2011. J. Cell Biol. doi:10.1083/jcb.201011051) provide an answer to this conundrum by showing that different concentrations of Wnt ligands can elicit different intracellular responses. These findings not only provide new insights into the molecular mechanisms underlying Wnt signaling, but also indicate how Wnt gradients might contribute to tissue patterning during embryogenesis. The Rockefeller University Press 2011-05-02 /pmc/articles/PMC3087014/ /pubmed/21536746 http://dx.doi.org/10.1083/jcb.201103167 Text en © 2011 Kestler and Kühl This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Kestler, Hans A.
Kühl, Michael
Generating a Wnt switch: it’s all about the right dosage
title Generating a Wnt switch: it’s all about the right dosage
title_full Generating a Wnt switch: it’s all about the right dosage
title_fullStr Generating a Wnt switch: it’s all about the right dosage
title_full_unstemmed Generating a Wnt switch: it’s all about the right dosage
title_short Generating a Wnt switch: it’s all about the right dosage
title_sort generating a wnt switch: it’s all about the right dosage
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087014/
https://www.ncbi.nlm.nih.gov/pubmed/21536746
http://dx.doi.org/10.1083/jcb.201103167
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