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Tetherin and Its Viral Antagonists

Restriction factors comprise an important layer of host defense to fight against viral infection. Some restriction factors are constitutively expressed whereas the majority is induced by interferon to elicit innate immunity. In addition to a number of well-characterized interferon-inducible antivira...

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Detalles Bibliográficos
Autores principales: Kuhl, Björn D., Cheng, Vicky, Wainberg, Mark A., Liang, Chen
Formato: Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087111/
https://www.ncbi.nlm.nih.gov/pubmed/21222046
http://dx.doi.org/10.1007/s11481-010-9256-1
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author Kuhl, Björn D.
Cheng, Vicky
Wainberg, Mark A.
Liang, Chen
author_facet Kuhl, Björn D.
Cheng, Vicky
Wainberg, Mark A.
Liang, Chen
author_sort Kuhl, Björn D.
collection PubMed
description Restriction factors comprise an important layer of host defense to fight against viral infection. Some restriction factors are constitutively expressed whereas the majority is induced by interferon to elicit innate immunity. In addition to a number of well-characterized interferon-inducible antiviral factors such as RNaseL/OAS, ISG15, Mx, PKR, and ADAR, tetherin (BST-2/CD317/HM1.24) was recently discovered to block the release of enveloped viruses from the cell surface, which is regarded as a novel antiviral mechanism induced by interferon. Here, we briefly review the history of tetherin discovery, discuss how tetherin blocks virus production, and highlight the viral countermeasures to evade tetherin restriction.
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spelling pubmed-30871112011-06-06 Tetherin and Its Viral Antagonists Kuhl, Björn D. Cheng, Vicky Wainberg, Mark A. Liang, Chen J Neuroimmune Pharmacol Invited Review Restriction factors comprise an important layer of host defense to fight against viral infection. Some restriction factors are constitutively expressed whereas the majority is induced by interferon to elicit innate immunity. In addition to a number of well-characterized interferon-inducible antiviral factors such as RNaseL/OAS, ISG15, Mx, PKR, and ADAR, tetherin (BST-2/CD317/HM1.24) was recently discovered to block the release of enveloped viruses from the cell surface, which is regarded as a novel antiviral mechanism induced by interferon. Here, we briefly review the history of tetherin discovery, discuss how tetherin blocks virus production, and highlight the viral countermeasures to evade tetherin restriction. Springer US 2011-01-11 2011 /pmc/articles/PMC3087111/ /pubmed/21222046 http://dx.doi.org/10.1007/s11481-010-9256-1 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Invited Review
Kuhl, Björn D.
Cheng, Vicky
Wainberg, Mark A.
Liang, Chen
Tetherin and Its Viral Antagonists
title Tetherin and Its Viral Antagonists
title_full Tetherin and Its Viral Antagonists
title_fullStr Tetherin and Its Viral Antagonists
title_full_unstemmed Tetherin and Its Viral Antagonists
title_short Tetherin and Its Viral Antagonists
title_sort tetherin and its viral antagonists
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087111/
https://www.ncbi.nlm.nih.gov/pubmed/21222046
http://dx.doi.org/10.1007/s11481-010-9256-1
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