DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

TAp63α, a homolog of the p53 tumor suppressor, is a quality control factor in the female germline. Remarkably, already undamaged oocytes express high levels of the protein, suggesting that TAp63α's activity is under tight control of an inhibitory mechanism. Biochemical studies have proposed tha...

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Detalles Bibliográficos
Autores principales: Deutsch, Gregor B., Zielonka, Elisabeth M., Coutandin, Daniel, Weber, Tobias A., Schäfer, Birgit, Hannewald, Jens, Luh, Laura M., Durst, Florian G., Ibrahim, Mohamed, Hoffmann, Jan, Niesen, Frank H., Sentürk, Aycan, Kunkel, Hana, Brutschy, Bernd, Schleiff, Enrico, Knapp, Stefan, Acker-Palmer, Amparo, Grez, Manuel, McKeon, Frank, Dötsch, Volker
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087504/
https://www.ncbi.nlm.nih.gov/pubmed/21335238
http://dx.doi.org/10.1016/j.cell.2011.01.013

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