Fiber optic microendoscopy for preclinical study of bacterial infection dynamics

We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 µm resolution, a 750 µm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal...

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Detalles Bibliográficos
Autores principales: Mufti, Nooman, Kong, Ying, Cirillo, Jeffrey D., Maitland, Kristen C.
Formato: Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Endoscopes, Catheters and Micro-Optics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087570/
https://www.ncbi.nlm.nih.gov/pubmed/21559125
http://dx.doi.org/10.1364/BOE.2.001121
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author Mufti, Nooman
Kong, Ying
Cirillo, Jeffrey D.
Maitland, Kristen C.
author_facet Mufti, Nooman
Kong, Ying
Cirillo, Jeffrey D.
Maitland, Kristen C.
author_sort Mufti, Nooman
collection PubMed
description We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 µm resolution, a 750 µm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detected in situ from inocula down to 10(4) and 10(7) colony forming units, respectively.
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spelling pubmed-30875702011-05-10 Fiber optic microendoscopy for preclinical study of bacterial infection dynamics Mufti, Nooman Kong, Ying Cirillo, Jeffrey D. Maitland, Kristen C. Biomed Opt Express Endoscopes, Catheters and Micro-Optics We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 µm resolution, a 750 µm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detected in situ from inocula down to 10(4) and 10(7) colony forming units, respectively. Optical Society of America 2011-04-07 /pmc/articles/PMC3087570/ /pubmed/21559125 http://dx.doi.org/10.1364/BOE.2.001121 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Endoscopes, Catheters and Micro-Optics
Mufti, Nooman
Kong, Ying
Cirillo, Jeffrey D.
Maitland, Kristen C.
Fiber optic microendoscopy for preclinical study of bacterial infection dynamics
title Fiber optic microendoscopy for preclinical study of bacterial infection dynamics
title_full Fiber optic microendoscopy for preclinical study of bacterial infection dynamics
title_fullStr Fiber optic microendoscopy for preclinical study of bacterial infection dynamics
title_full_unstemmed Fiber optic microendoscopy for preclinical study of bacterial infection dynamics
title_short Fiber optic microendoscopy for preclinical study of bacterial infection dynamics
title_sort fiber optic microendoscopy for preclinical study of bacterial infection dynamics
topic Endoscopes, Catheters and Micro-Optics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087570/
https://www.ncbi.nlm.nih.gov/pubmed/21559125
http://dx.doi.org/10.1364/BOE.2.001121
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