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Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line

Swept-source optical coherence tomography (SSOCT) provides a substantial sensitivity advantage over its time-domain counterpart, but suffers from a reduced imaging depth range due to sensitivity falloff and complex conjugate ambiguity. Heterodyne complex conjugate-resolved SSOCT (HCCR-SSOCT) has bee...

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Autores principales: Dhalla, Al-Hafeez, Izatt, Joseph A.
Formato: Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087578/
https://www.ncbi.nlm.nih.gov/pubmed/21559133
http://dx.doi.org/10.1364/BOE.2.001218
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author Dhalla, Al-Hafeez
Izatt, Joseph A.
author_facet Dhalla, Al-Hafeez
Izatt, Joseph A.
author_sort Dhalla, Al-Hafeez
collection PubMed
description Swept-source optical coherence tomography (SSOCT) provides a substantial sensitivity advantage over its time-domain counterpart, but suffers from a reduced imaging depth range due to sensitivity falloff and complex conjugate ambiguity. Heterodyne complex conjugate-resolved SSOCT (HCCR-SSOCT) has been previously demonstrated as a technique to completely resolve the complex conjugate ambiguity, effectively doubling the falloff limited imaging depth, without the reduction in imaging speed associated with other CCR techniques. However, previous implementations of this technique have employed expensive and lossy optical modulators to provide the required differential phase modulation. In this paper, we demonstrate the use of a dispersive optical delay line (D-ODL) as the reference arm of an OCT system to realize HCCR-SSOCT. This technique maintains the existing advantages of HCCR-SSOCT in that it completely resolves the complex conjugate artifact and does not reduce imaging speed, while conferring the additional advantages of being low cost, maintaining system sensitivity and resolution, not requiring any additional signal processing, and working at all wavelengths and imaging speeds. The D-ODL also allows for hardware correction of unbalanced dispersion in the reference and sample arm, adding further flexibility to system design. We demonstrate the technique using an SSOCT system operating at 100kHz with a central wavelength of 1040nm. Falloff measurements performed using a standard OCT configuration and the proposed D-ODL demonstrate a doubling of the effective imaging range with no sensitivity or resolution penalty. Feasibility of the technique for in vivo imaging was demonstrated by imaging the ocular anterior segments of healthy human volunteers.
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spelling pubmed-30875782011-05-10 Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line Dhalla, Al-Hafeez Izatt, Joseph A. Biomed Opt Express Optical Coherence Tomography Swept-source optical coherence tomography (SSOCT) provides a substantial sensitivity advantage over its time-domain counterpart, but suffers from a reduced imaging depth range due to sensitivity falloff and complex conjugate ambiguity. Heterodyne complex conjugate-resolved SSOCT (HCCR-SSOCT) has been previously demonstrated as a technique to completely resolve the complex conjugate ambiguity, effectively doubling the falloff limited imaging depth, without the reduction in imaging speed associated with other CCR techniques. However, previous implementations of this technique have employed expensive and lossy optical modulators to provide the required differential phase modulation. In this paper, we demonstrate the use of a dispersive optical delay line (D-ODL) as the reference arm of an OCT system to realize HCCR-SSOCT. This technique maintains the existing advantages of HCCR-SSOCT in that it completely resolves the complex conjugate artifact and does not reduce imaging speed, while conferring the additional advantages of being low cost, maintaining system sensitivity and resolution, not requiring any additional signal processing, and working at all wavelengths and imaging speeds. The D-ODL also allows for hardware correction of unbalanced dispersion in the reference and sample arm, adding further flexibility to system design. We demonstrate the technique using an SSOCT system operating at 100kHz with a central wavelength of 1040nm. Falloff measurements performed using a standard OCT configuration and the proposed D-ODL demonstrate a doubling of the effective imaging range with no sensitivity or resolution penalty. Feasibility of the technique for in vivo imaging was demonstrated by imaging the ocular anterior segments of healthy human volunteers. Optical Society of America 2011-04-15 /pmc/articles/PMC3087578/ /pubmed/21559133 http://dx.doi.org/10.1364/BOE.2.001218 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Optical Coherence Tomography
Dhalla, Al-Hafeez
Izatt, Joseph A.
Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line
title Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line
title_full Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line
title_fullStr Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line
title_full_unstemmed Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line
title_short Complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line
title_sort complete complex conjugate resolved heterodyne swept-source optical coherence tomography using a dispersive optical delay line
topic Optical Coherence Tomography
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087578/
https://www.ncbi.nlm.nih.gov/pubmed/21559133
http://dx.doi.org/10.1364/BOE.2.001218
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