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Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties
The information from spectral reflectance of articular cartilage has been related to the integrity of the tissue. This study explores more in detail the interrelations between the cartilage composition, structure and mechanical properties, and optical spectral reflectance. Using human osteochondral...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087595/ https://www.ncbi.nlm.nih.gov/pubmed/21559150 http://dx.doi.org/10.1364/BOE.2.001394 |
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author | Kinnunen, Jussi Saarakkala, Simo Hauta-Kasari, Markku Vahimaa, Pasi Jurvelin, Jukka S. |
author_facet | Kinnunen, Jussi Saarakkala, Simo Hauta-Kasari, Markku Vahimaa, Pasi Jurvelin, Jukka S. |
author_sort | Kinnunen, Jussi |
collection | PubMed |
description | The information from spectral reflectance of articular cartilage has been related to the integrity of the tissue. This study explores more in detail the interrelations between the cartilage composition, structure and mechanical properties, and optical spectral reflectance. Using human osteochondral samples the reflectance spectral images of articular cartilage were captured and analyzed by using CIELAB color space as well as principal component analysis. With both analysis methods statistically significant correlations were observed between the reflectance and histological integrity, as assessed by Mankin scoring, tissue proteoglycan content and dynamic modulus. In thick human cartilage, the reflectance was found to be independent of the cartilage thickness, suggesting negligible influence of the underlying subchondral bone. Based on the present results diagnostically relevant information on cartilage quality can be extracted using optical spectral reflectance measurements. These measurements could be feasible during arthroscopic surgery when more in-depth information of the properties of articular cartilage is needed. |
format | Text |
id | pubmed-3087595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-30875952011-05-10 Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties Kinnunen, Jussi Saarakkala, Simo Hauta-Kasari, Markku Vahimaa, Pasi Jurvelin, Jukka S. Biomed Opt Express Spectroscopic Diagnostics The information from spectral reflectance of articular cartilage has been related to the integrity of the tissue. This study explores more in detail the interrelations between the cartilage composition, structure and mechanical properties, and optical spectral reflectance. Using human osteochondral samples the reflectance spectral images of articular cartilage were captured and analyzed by using CIELAB color space as well as principal component analysis. With both analysis methods statistically significant correlations were observed between the reflectance and histological integrity, as assessed by Mankin scoring, tissue proteoglycan content and dynamic modulus. In thick human cartilage, the reflectance was found to be independent of the cartilage thickness, suggesting negligible influence of the underlying subchondral bone. Based on the present results diagnostically relevant information on cartilage quality can be extracted using optical spectral reflectance measurements. These measurements could be feasible during arthroscopic surgery when more in-depth information of the properties of articular cartilage is needed. Optical Society of America 2011-04-29 /pmc/articles/PMC3087595/ /pubmed/21559150 http://dx.doi.org/10.1364/BOE.2.001394 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Spectroscopic Diagnostics Kinnunen, Jussi Saarakkala, Simo Hauta-Kasari, Markku Vahimaa, Pasi Jurvelin, Jukka S. Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties |
title | Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties |
title_full | Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties |
title_fullStr | Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties |
title_full_unstemmed | Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties |
title_short | Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties |
title_sort | optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties |
topic | Spectroscopic Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087595/ https://www.ncbi.nlm.nih.gov/pubmed/21559150 http://dx.doi.org/10.1364/BOE.2.001394 |
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