Fosmidomycin Uptake into Plasmodium and Babesia-Infected Erythrocytes Is Facilitated by Parasite-Induced New Permeability Pathways

BACKGROUND: Highly charged compounds typically suffer from low membrane permeability and thus are generally regarded as sub-optimal drug candidates. Nonetheless, the highly charged drug fosmidomycin and its more active methyl-derivative FR900098 have proven parasiticidal activity against erythrocyti...

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Detalles Bibliográficos
Autores principales: Baumeister, Stefan, Wiesner, Jochen, Reichenberg, Armin, Hintz, Martin, Bietz, Sven, Harb, Omar S., Roos, David S., Kordes, Maximilian, Friesen, Johannes, Matuschewski, Kai, Lingelbach, Klaus, Jomaa, Hassan, Seeber, Frank
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087763/
https://www.ncbi.nlm.nih.gov/pubmed/21573242
http://dx.doi.org/10.1371/journal.pone.0019334

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