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Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications
Inteins self-splice from precursor polypeptides to reconstitute functional proteins. Here we describe inteins as redox-responsive switches in bacteria. Regulation was achieved by engineering a disulfide bond between the intein’s catalytic cysteine and the flanking polypeptide. This interaction was v...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087850/ https://www.ncbi.nlm.nih.gov/pubmed/21460844 http://dx.doi.org/10.1038/nsmb.2041 |