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Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma

Background. There remains controversy on the routine use of chemotherapy in localized SS. Methods. The records of 87 adult (AP) and 15 pediatric (PP) patients with localized SS diagnosed between 1986 and 2007 at 2 centres in Toronto were reviewed. Results. Median age for AP and PP was 37.6 (range 15...

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Autores principales: Al-Hussaini, H., Hogg, D., Blackstein, M. E., O'Sullivan, B., Catton, C. N., Chung, P. W., Griffin, A. M., Hodgson, D., Hopyan, S., Kandel, R., Ferguson, P. C., Wunder, J. S., Gupta, A. A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087894/
https://www.ncbi.nlm.nih.gov/pubmed/21559258
http://dx.doi.org/10.1155/2011/231789
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author Al-Hussaini, H.
Hogg, D.
Blackstein, M. E.
O'Sullivan, B.
Catton, C. N.
Chung, P. W.
Griffin, A. M.
Hodgson, D.
Hopyan, S.
Kandel, R.
Ferguson, P. C.
Wunder, J. S.
Gupta, A. A.
author_facet Al-Hussaini, H.
Hogg, D.
Blackstein, M. E.
O'Sullivan, B.
Catton, C. N.
Chung, P. W.
Griffin, A. M.
Hodgson, D.
Hopyan, S.
Kandel, R.
Ferguson, P. C.
Wunder, J. S.
Gupta, A. A.
author_sort Al-Hussaini, H.
collection PubMed
description Background. There remains controversy on the routine use of chemotherapy in localized SS. Methods. The records of 87 adult (AP) and 15 pediatric (PP) patients with localized SS diagnosed between 1986 and 2007 at 2 centres in Toronto were reviewed. Results. Median age for AP and PP was 37.6 (range 15–76) and 14 (range 0.4–18) years, respectively. 65 (64%) patients had large tumours (>5 cm). All patients underwent en bloc surgical resection resulting in 94 (92.2%) negative and 8 (7.8%) microscopically positive surgical margins. 72 (82.8%) AP and 8 (53%) PP received radiotherapy. Chemotherapy was administered to 12 (13.8%) AP and 13 (87%) PP. 10 AP and 5 PP were evaluable for response to neoadjuvant chemotherapy, with response rate of 10% and 40%, respectively. 5-year EFS and OS was 69.3 ± 4.8% and 80.3 ± 4.3%, respectively, and was similar for AP and PP, In patients with tumors >5 cm, in whom chemotherapy might be considered most appropriate, relapse occurred in 9/19 (47%) with chemotherapy, compared to 17/46 (37%) In those without. Conclusions. Patients with localized SS have a good chance of cure with surgery and RT. Evidence for a well-defined role of chemotherapy to improve survival In localized SS remains elusive.
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spelling pubmed-30878942011-05-10 Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma Al-Hussaini, H. Hogg, D. Blackstein, M. E. O'Sullivan, B. Catton, C. N. Chung, P. W. Griffin, A. M. Hodgson, D. Hopyan, S. Kandel, R. Ferguson, P. C. Wunder, J. S. Gupta, A. A. Sarcoma Research Article Background. There remains controversy on the routine use of chemotherapy in localized SS. Methods. The records of 87 adult (AP) and 15 pediatric (PP) patients with localized SS diagnosed between 1986 and 2007 at 2 centres in Toronto were reviewed. Results. Median age for AP and PP was 37.6 (range 15–76) and 14 (range 0.4–18) years, respectively. 65 (64%) patients had large tumours (>5 cm). All patients underwent en bloc surgical resection resulting in 94 (92.2%) negative and 8 (7.8%) microscopically positive surgical margins. 72 (82.8%) AP and 8 (53%) PP received radiotherapy. Chemotherapy was administered to 12 (13.8%) AP and 13 (87%) PP. 10 AP and 5 PP were evaluable for response to neoadjuvant chemotherapy, with response rate of 10% and 40%, respectively. 5-year EFS and OS was 69.3 ± 4.8% and 80.3 ± 4.3%, respectively, and was similar for AP and PP, In patients with tumors >5 cm, in whom chemotherapy might be considered most appropriate, relapse occurred in 9/19 (47%) with chemotherapy, compared to 17/46 (37%) In those without. Conclusions. Patients with localized SS have a good chance of cure with surgery and RT. Evidence for a well-defined role of chemotherapy to improve survival In localized SS remains elusive. Hindawi Publishing Corporation 2011 2011-04-14 /pmc/articles/PMC3087894/ /pubmed/21559258 http://dx.doi.org/10.1155/2011/231789 Text en Copyright © 2011 H. Al-Hussaini et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Al-Hussaini, H.
Hogg, D.
Blackstein, M. E.
O'Sullivan, B.
Catton, C. N.
Chung, P. W.
Griffin, A. M.
Hodgson, D.
Hopyan, S.
Kandel, R.
Ferguson, P. C.
Wunder, J. S.
Gupta, A. A.
Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma
title Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma
title_full Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma
title_fullStr Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma
title_full_unstemmed Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma
title_short Clinical Features, Treatment, and Outcome in 102 Adult and Pediatric Patients with Localized High-Grade Synovial Sarcoma
title_sort clinical features, treatment, and outcome in 102 adult and pediatric patients with localized high-grade synovial sarcoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087894/
https://www.ncbi.nlm.nih.gov/pubmed/21559258
http://dx.doi.org/10.1155/2011/231789
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