Cargando…
Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation
Non-human primates (NHPs) are a very valuable experimental model for diabetes research studies including experimental pancreatic islet transplantation. In particular NHPs are the recipients of choice to validate pigs as possible source of pancreatic islets. The aim of this study was to quantify glyc...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087943/ https://www.ncbi.nlm.nih.gov/pubmed/21559266 http://dx.doi.org/10.1155/2011/965605 |
_version_ | 1782202838008463360 |
---|---|
author | Marigliano, Marco Casu, Anna Bertera, Suzanne Trucco, Massimo Bottino, Rita |
author_facet | Marigliano, Marco Casu, Anna Bertera, Suzanne Trucco, Massimo Bottino, Rita |
author_sort | Marigliano, Marco |
collection | PubMed |
description | Non-human primates (NHPs) are a very valuable experimental model for diabetes research studies including experimental pancreatic islet transplantation. In particular NHPs are the recipients of choice to validate pigs as possible source of pancreatic islets. The aim of this study was to quantify glycated hemoglobin percentage in NHPs and to assess whether changes in values reflect the metabolic trends after diabetes induction and islet transplantation. Sera from 15 NHPs were analyzed. 9 NHPs were rendered diabetic with streptozotocin (STZ), and 3 of them received porcine islet transplants. Hemoglobin A1c (HbA1c) percentage was measured with an assay based on a latex immunoagglutination inhibition methodology. Whereas diabetes and its duration were associated with increasing HbA1c levels, postislet transplantation blood glucose normalization was paralleled by a decrease in the HbA1c percentage. Our data provide evidence that HbA1c is a useful tool to monitor glucose metabolism in NHPs. |
format | Text |
id | pubmed-3087943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30879432011-05-10 Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation Marigliano, Marco Casu, Anna Bertera, Suzanne Trucco, Massimo Bottino, Rita J Transplant Research Article Non-human primates (NHPs) are a very valuable experimental model for diabetes research studies including experimental pancreatic islet transplantation. In particular NHPs are the recipients of choice to validate pigs as possible source of pancreatic islets. The aim of this study was to quantify glycated hemoglobin percentage in NHPs and to assess whether changes in values reflect the metabolic trends after diabetes induction and islet transplantation. Sera from 15 NHPs were analyzed. 9 NHPs were rendered diabetic with streptozotocin (STZ), and 3 of them received porcine islet transplants. Hemoglobin A1c (HbA1c) percentage was measured with an assay based on a latex immunoagglutination inhibition methodology. Whereas diabetes and its duration were associated with increasing HbA1c levels, postislet transplantation blood glucose normalization was paralleled by a decrease in the HbA1c percentage. Our data provide evidence that HbA1c is a useful tool to monitor glucose metabolism in NHPs. Hindawi Publishing Corporation 2011 2011-04-17 /pmc/articles/PMC3087943/ /pubmed/21559266 http://dx.doi.org/10.1155/2011/965605 Text en Copyright © 2011 Marco Marigliano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Marigliano, Marco Casu, Anna Bertera, Suzanne Trucco, Massimo Bottino, Rita Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation |
title | Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation |
title_full | Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation |
title_fullStr | Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation |
title_full_unstemmed | Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation |
title_short | Hemoglobin A1C Percentage in Nonhuman Primates: A Useful Tool to Monitor Diabetes before and after Porcine Pancreatic Islet Xenotransplantation |
title_sort | hemoglobin a1c percentage in nonhuman primates: a useful tool to monitor diabetes before and after porcine pancreatic islet xenotransplantation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087943/ https://www.ncbi.nlm.nih.gov/pubmed/21559266 http://dx.doi.org/10.1155/2011/965605 |
work_keys_str_mv | AT mariglianomarco hemoglobina1cpercentageinnonhumanprimatesausefultooltomonitordiabetesbeforeandafterporcinepancreaticisletxenotransplantation AT casuanna hemoglobina1cpercentageinnonhumanprimatesausefultooltomonitordiabetesbeforeandafterporcinepancreaticisletxenotransplantation AT berterasuzanne hemoglobina1cpercentageinnonhumanprimatesausefultooltomonitordiabetesbeforeandafterporcinepancreaticisletxenotransplantation AT truccomassimo hemoglobina1cpercentageinnonhumanprimatesausefultooltomonitordiabetesbeforeandafterporcinepancreaticisletxenotransplantation AT bottinorita hemoglobina1cpercentageinnonhumanprimatesausefultooltomonitordiabetesbeforeandafterporcinepancreaticisletxenotransplantation |