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The Molecular Pathogenesis of Osteosarcoma: A Review

Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60%–70%, with no significant improvements in prognosis since the advent of multiagent chemothe...

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Detalles Bibliográficos
Autores principales: Broadhead, Matthew L., Clark, Jonathan C. M., Myers, Damian E., Dass, Crispin R., Choong, Peter F. M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087974/
https://www.ncbi.nlm.nih.gov/pubmed/21559216
http://dx.doi.org/10.1155/2011/959248
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author Broadhead, Matthew L.
Clark, Jonathan C. M.
Myers, Damian E.
Dass, Crispin R.
Choong, Peter F. M.
author_facet Broadhead, Matthew L.
Clark, Jonathan C. M.
Myers, Damian E.
Dass, Crispin R.
Choong, Peter F. M.
author_sort Broadhead, Matthew L.
collection PubMed
description Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60%–70%, with no significant improvements in prognosis since the advent of multiagent chemotherapy. Diagnosis, staging, and surgical management of osteosarcoma remain focused on our anatomical understanding of the disease. As our knowledge of the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified. A comprehensive understanding of these mechanisms is essential if we are to improve the prognosis of patients with osteosarcoma through tumour-targeted therapies. This paper will outline the pathogenic mechanisms of osteosarcoma oncogenesis and progression and will discuss some of the more frontline translational studies performed to date in search of novel, safer, and more targeted drugs for disease management.
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spelling pubmed-30879742011-05-10 The Molecular Pathogenesis of Osteosarcoma: A Review Broadhead, Matthew L. Clark, Jonathan C. M. Myers, Damian E. Dass, Crispin R. Choong, Peter F. M. Sarcoma Review Article Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60%–70%, with no significant improvements in prognosis since the advent of multiagent chemotherapy. Diagnosis, staging, and surgical management of osteosarcoma remain focused on our anatomical understanding of the disease. As our knowledge of the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified. A comprehensive understanding of these mechanisms is essential if we are to improve the prognosis of patients with osteosarcoma through tumour-targeted therapies. This paper will outline the pathogenic mechanisms of osteosarcoma oncogenesis and progression and will discuss some of the more frontline translational studies performed to date in search of novel, safer, and more targeted drugs for disease management. Hindawi Publishing Corporation 2011 2011-04-13 /pmc/articles/PMC3087974/ /pubmed/21559216 http://dx.doi.org/10.1155/2011/959248 Text en Copyright © 2011 Matthew L. Broadhead et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Broadhead, Matthew L.
Clark, Jonathan C. M.
Myers, Damian E.
Dass, Crispin R.
Choong, Peter F. M.
The Molecular Pathogenesis of Osteosarcoma: A Review
title The Molecular Pathogenesis of Osteosarcoma: A Review
title_full The Molecular Pathogenesis of Osteosarcoma: A Review
title_fullStr The Molecular Pathogenesis of Osteosarcoma: A Review
title_full_unstemmed The Molecular Pathogenesis of Osteosarcoma: A Review
title_short The Molecular Pathogenesis of Osteosarcoma: A Review
title_sort molecular pathogenesis of osteosarcoma: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087974/
https://www.ncbi.nlm.nih.gov/pubmed/21559216
http://dx.doi.org/10.1155/2011/959248
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