Macrophages and Cell-Cell Spread of HIV-1

Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of vir...

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Detalles Bibliográficos
Autores principales: Waki, Kayoko, Freed, Eric O.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088113/
https://www.ncbi.nlm.nih.gov/pubmed/21552427
http://dx.doi.org/10.3390/v2081603
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author Waki, Kayoko
Freed, Eric O.
author_facet Waki, Kayoko
Freed, Eric O.
author_sort Waki, Kayoko
collection PubMed
description Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages.
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spelling pubmed-30881132011-05-05 Macrophages and Cell-Cell Spread of HIV-1 Waki, Kayoko Freed, Eric O. Viruses Review Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is central to our understanding of HIV-1 pathogenesis and progression to AIDS, and is vital to the development of vaccines and novel antiretroviral therapies. This review provides an overview of the current understanding of cell-cell transmission in macrophages. Molecular Diversity Preservation International (MDPI) 2010-08-05 /pmc/articles/PMC3088113/ /pubmed/21552427 http://dx.doi.org/10.3390/v2081603 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Waki, Kayoko
Freed, Eric O.
Macrophages and Cell-Cell Spread of HIV-1
title Macrophages and Cell-Cell Spread of HIV-1
title_full Macrophages and Cell-Cell Spread of HIV-1
title_fullStr Macrophages and Cell-Cell Spread of HIV-1
title_full_unstemmed Macrophages and Cell-Cell Spread of HIV-1
title_short Macrophages and Cell-Cell Spread of HIV-1
title_sort macrophages and cell-cell spread of hiv-1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088113/
https://www.ncbi.nlm.nih.gov/pubmed/21552427
http://dx.doi.org/10.3390/v2081603
work_keys_str_mv AT wakikayoko macrophagesandcellcellspreadofhiv1
AT freederico macrophagesandcellcellspreadofhiv1

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