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Fishing Pluripotency Mechanisms In Vivo
To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to us...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088283/ https://www.ncbi.nlm.nih.gov/pubmed/21547058 |
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author | Sánchez-Sánchez, Ana V. Camp, Esther Mullor, José L. |
author_facet | Sánchez-Sánchez, Ana V. Camp, Esther Mullor, José L. |
author_sort | Sánchez-Sánchez, Ana V. |
collection | PubMed |
description | To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency in vivo. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency. |
format | Text |
id | pubmed-3088283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-30882832011-05-05 Fishing Pluripotency Mechanisms In Vivo Sánchez-Sánchez, Ana V. Camp, Esther Mullor, José L. Int J Biol Sci Review To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency in vivo. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency. Ivyspring International Publisher 2011-04-15 /pmc/articles/PMC3088283/ /pubmed/21547058 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Review Sánchez-Sánchez, Ana V. Camp, Esther Mullor, José L. Fishing Pluripotency Mechanisms In Vivo |
title | Fishing Pluripotency Mechanisms In Vivo |
title_full | Fishing Pluripotency Mechanisms In Vivo |
title_fullStr | Fishing Pluripotency Mechanisms In Vivo |
title_full_unstemmed | Fishing Pluripotency Mechanisms In Vivo |
title_short | Fishing Pluripotency Mechanisms In Vivo |
title_sort | fishing pluripotency mechanisms in vivo |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088283/ https://www.ncbi.nlm.nih.gov/pubmed/21547058 |
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