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Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E(2) Synthase-1 (mPGES-1)

[Image: see text] Microsomal prostaglandin E(2) synthase-1 (mPGES-1) catalyzes prostaglandin E(2) formation and is considered as a potential anti-inflammatory pharmacological target. To identify novel chemical scaffolds active on this enzyme, two pharmacophore models for acidic mPGES-1 inhibitors we...

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Detalles Bibliográficos
Autores principales:	Waltenberger, Birgit, Wiechmann, Katja, Bauer, Julia, Markt, Patrick, Noha, Stefan M., Wolber, Gerhard, Rollinger, Judith M., Werz, Oliver, Schuster, Daniela, Stuppner, Hermann
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088311/ https://www.ncbi.nlm.nih.gov/pubmed/21466167 http://dx.doi.org/10.1021/jm101309g

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