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Modeling Evolutionary Dynamics of Epigenetic Mutations in Hierarchically Organized Tumors

The cancer stem cell (CSC) concept is a highly debated topic in cancer research. While experimental evidence in favor of the cancer stem cell theory is apparently abundant, the results are often criticized as being difficult to interpret. An important reason for this is that most experimental data t...

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Detalles Bibliográficos
Autores principales: Sottoriva, Andrea, Vermeulen, Louis, Tavaré, Simon
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088646/
https://www.ncbi.nlm.nih.gov/pubmed/21573198
http://dx.doi.org/10.1371/journal.pcbi.1001132