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Nuclear cGMP-Dependent Kinase Regulates Gene Expression via Activity-Dependent Recruitment of a Conserved Histone Deacetylase Complex

Elevation of the second messenger cGMP by nitric oxide (NO) activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals. The NO-cGMP-PKG signaling pathway is also a major therapeutic target for cardiovascular and male repr...

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Detalles Bibliográficos
Autores principales:	Hao, Yan, Xu, Ningyi, Box, Andrew C., Schaefer, Laura, Kannan, Kasthuri, Zhang, Ying, Florens, Laurence, Seidel, Christopher, Washburn, Michael P., Wiegraebe, Winfried, Mak, Ho Yi
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088716/ https://www.ncbi.nlm.nih.gov/pubmed/21573134 http://dx.doi.org/10.1371/journal.pgen.1002065

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