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The complexity of ToxT-dependent transcription in Vibrio cholerae

Vibrio cholerae is the causative agent of the disease cholera, characterized by profuse watery diarrhoea. Two of the main virulence factors associated with the disease are cholera toxin (CT) and toxin-coregulated pilus (TCP). Expression of CT and TCP is regulated via a complex cascade of factors tha...

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Autores principales: Weber, Gregor G., Klose, Karl E., Klose
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089052/
https://www.ncbi.nlm.nih.gov/pubmed/21415495
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author Weber, Gregor G.
Klose, Karl E.
Klose,
author_facet Weber, Gregor G.
Klose, Karl E.
Klose,
author_sort Weber, Gregor G.
collection PubMed
description Vibrio cholerae is the causative agent of the disease cholera, characterized by profuse watery diarrhoea. Two of the main virulence factors associated with the disease are cholera toxin (CT) and toxin-coregulated pilus (TCP). Expression of CT and TCP is regulated via a complex cascade of factors that respond to environmental signals, but ultimately ToxT is the direct transcriptional activator of the genes encoding CT and TCP. Recent studies have begun to unveil the mechanisms behind ToxT-dependent transcription. We review current knowledge of transcriptional activation by ToxT and the environmental stimuli that allow ToxT to regulate virulence gene expression, resulting in cholera pathogenesis.
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spelling pubmed-30890522011-05-16 The complexity of ToxT-dependent transcription in Vibrio cholerae Weber, Gregor G. Klose, Karl E. Klose, Indian J Med Res Review Article Vibrio cholerae is the causative agent of the disease cholera, characterized by profuse watery diarrhoea. Two of the main virulence factors associated with the disease are cholera toxin (CT) and toxin-coregulated pilus (TCP). Expression of CT and TCP is regulated via a complex cascade of factors that respond to environmental signals, but ultimately ToxT is the direct transcriptional activator of the genes encoding CT and TCP. Recent studies have begun to unveil the mechanisms behind ToxT-dependent transcription. We review current knowledge of transcriptional activation by ToxT and the environmental stimuli that allow ToxT to regulate virulence gene expression, resulting in cholera pathogenesis. Medknow Publications 2011-02 /pmc/articles/PMC3089052/ /pubmed/21415495 Text en © The Indian Journal of Medical Research http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Weber, Gregor G.
Klose, Karl E.
Klose,
The complexity of ToxT-dependent transcription in Vibrio cholerae
title The complexity of ToxT-dependent transcription in Vibrio cholerae
title_full The complexity of ToxT-dependent transcription in Vibrio cholerae
title_fullStr The complexity of ToxT-dependent transcription in Vibrio cholerae
title_full_unstemmed The complexity of ToxT-dependent transcription in Vibrio cholerae
title_short The complexity of ToxT-dependent transcription in Vibrio cholerae
title_sort complexity of toxt-dependent transcription in vibrio cholerae
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089052/
https://www.ncbi.nlm.nih.gov/pubmed/21415495
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