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(1S*,4′S*,5R*)-1-Isopropyl-5-meth­oxy-2′,3-dimethyl-4,6-dioxa-2-aza­spiro­[bicyclo­[3.2.0]hept-2-ene-7,4′-isoquinoline]-1′,3′(2′H,4′H)-dione

In the isoquinoline ring system of the title mol­ecule, C(18)H(20)N(2)O(5), the N-heterocyclic ring is in a half-boat conformation. The dioxa-2-aza­spiro ring is essentially planar, with a maximum deviation of 0.029 (1) Å, and makes a dihedral angle of 30.63 (5)° with the benzene ring. The mol­ecula...

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Detalles Bibliográficos
Autores principales: Fun, Hoong-Kun, Quah, Ching Kheng, Huang, Chengmei, Yu, Haitao
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089152/
https://www.ncbi.nlm.nih.gov/pubmed/21754556
http://dx.doi.org/10.1107/S1600536811015315
Descripción
Sumario:In the isoquinoline ring system of the title mol­ecule, C(18)H(20)N(2)O(5), the N-heterocyclic ring is in a half-boat conformation. The dioxa-2-aza­spiro ring is essentially planar, with a maximum deviation of 0.029 (1) Å, and makes a dihedral angle of 30.63 (5)° with the benzene ring. The mol­ecular structure is stabilized by a weak intra­molecular C—H⋯O hydrogen bond, which generates a S(6) ring motif. In the crystal, mol­ecules are linked via weak inter­molecular C—H⋯O hydrogen bonds into a three-dimensional supra­molecular network. Additional stabilization is provided by π–π stacking inter­actions between symmetry-related benzene rings with a centroid–centroid distance of 3.6507 (5) Å.