Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA

Endogenous 5-methylcytosine ((Me)C) residues are found at all CG dinucleotides of the p53 tumor suppressor gene, including the mutational ‘hotspots’ for smoking induced lung cancer. (Me)C enhances the reactivity of its base paired guanine towards carcinogenic diolepoxide metabolites of polycyclic ar...

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Detalles Bibliográficos
Autores principales: Guza, Rebecca, Kotandeniya, Delshanee, Murphy, Kristopher, Dissanayake, Thakshila, Lin, Chen, Giambasu, George Madalin, Lad, Rahul R., Wojciechowski, Filip, Amin, Shantu, Sturla, Shana J., Hudson, Robert H.E., York, Darrin M., Jankowiak, Ryszard, Jones, Roger, Tretyakova, Natalia Y.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089471/
https://www.ncbi.nlm.nih.gov/pubmed/21245046
http://dx.doi.org/10.1093/nar/gkq1341

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