Daily Treatment with SMTC1100, a Novel Small Molecule Utrophin Upregulator, Dramatically Reduces the Dystrophic Symptoms in the mdx Mouse

BACKGROUND: Duchenne muscular dystrophy (DMD) is a lethal, progressive muscle wasting disease caused by a loss of sarcolemmal bound dystrophin, which results in the death of the muscle fibers leading to the gradual depletion of skeletal muscle. There is significant evidence demonstrating that increa...

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Detalles Bibliográficos
Autores principales: Tinsley, Jonathon M., Fairclough, Rebecca J., Storer, Richard, Wilkes, Fraser J., Potter, Allyson C., Squire, Sarah E., Powell, Dave S., Cozzoli, Anna, Capogrosso, Roberta F., Lambert, Adam, Wilson, Francis X., Wren, Stephen P., De Luca, Annamaria, Davies, Kay E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089598/
https://www.ncbi.nlm.nih.gov/pubmed/21573153
http://dx.doi.org/10.1371/journal.pone.0019189

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