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Electromyographic Activity in the EEG in Alzheimer's Disease: Noise or Signal?

Many efforts have been directed at negating the influence of electromyographic (EMG) activity on the EEG, especially in elderly demented patients. We wondered whether these “artifacts” might reflect cognitive and behavioural aspects of dementia. In this pilot study, 11 patients with probable Alzheim...

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Autores principales: van der Hiele, Karin, Reijntjes, Robert H. A. M., Vein, Alla A., Westendorp, Rudi G. J., van Buchem, Mark A., Bollen, Eduard L. E. M., Middelkoop, Huub A. M., van Dijk, J. Gert
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089836/
https://www.ncbi.nlm.nih.gov/pubmed/21559240
http://dx.doi.org/10.4061/2011/547024
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author van der Hiele, Karin
Reijntjes, Robert H. A. M.
Vein, Alla A.
Westendorp, Rudi G. J.
van Buchem, Mark A.
Bollen, Eduard L. E. M.
Middelkoop, Huub A. M.
van Dijk, J. Gert
author_facet van der Hiele, Karin
Reijntjes, Robert H. A. M.
Vein, Alla A.
Westendorp, Rudi G. J.
van Buchem, Mark A.
Bollen, Eduard L. E. M.
Middelkoop, Huub A. M.
van Dijk, J. Gert
author_sort van der Hiele, Karin
collection PubMed
description Many efforts have been directed at negating the influence of electromyographic (EMG) activity on the EEG, especially in elderly demented patients. We wondered whether these “artifacts” might reflect cognitive and behavioural aspects of dementia. In this pilot study, 11 patients with probable Alzheimer's disease (AD), 13 with amnestic mild cognitive impairment (MCI) and 13 controls underwent EEG registration. As EMG measures, we used frontal and temporal 50–70 Hz activity. We found that the EEGs of AD patients displayed more theta activity, less alpha reactivity, and more frontal EMG than controls. Interestingly, increased EMG activity indicated more cognitive impairment and more depressive complaints. EEG variables on the whole distinguished better between groups than EMG variables, but an EMG variable was best for the distinction between MCI and controls. Our results suggest that EMG activity in the EEG could be more than noise; it differs systematically between groups and may reflect different cerebral functions than the EEG.
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spelling pubmed-30898362011-05-10 Electromyographic Activity in the EEG in Alzheimer's Disease: Noise or Signal? van der Hiele, Karin Reijntjes, Robert H. A. M. Vein, Alla A. Westendorp, Rudi G. J. van Buchem, Mark A. Bollen, Eduard L. E. M. Middelkoop, Huub A. M. van Dijk, J. Gert Int J Alzheimers Dis Clinical Study Many efforts have been directed at negating the influence of electromyographic (EMG) activity on the EEG, especially in elderly demented patients. We wondered whether these “artifacts” might reflect cognitive and behavioural aspects of dementia. In this pilot study, 11 patients with probable Alzheimer's disease (AD), 13 with amnestic mild cognitive impairment (MCI) and 13 controls underwent EEG registration. As EMG measures, we used frontal and temporal 50–70 Hz activity. We found that the EEGs of AD patients displayed more theta activity, less alpha reactivity, and more frontal EMG than controls. Interestingly, increased EMG activity indicated more cognitive impairment and more depressive complaints. EEG variables on the whole distinguished better between groups than EMG variables, but an EMG variable was best for the distinction between MCI and controls. Our results suggest that EMG activity in the EEG could be more than noise; it differs systematically between groups and may reflect different cerebral functions than the EEG. SAGE-Hindawi Access to Research 2011-03-29 /pmc/articles/PMC3089836/ /pubmed/21559240 http://dx.doi.org/10.4061/2011/547024 Text en Copyright © 2011 Karin van der Hiele et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
van der Hiele, Karin
Reijntjes, Robert H. A. M.
Vein, Alla A.
Westendorp, Rudi G. J.
van Buchem, Mark A.
Bollen, Eduard L. E. M.
Middelkoop, Huub A. M.
van Dijk, J. Gert
Electromyographic Activity in the EEG in Alzheimer's Disease: Noise or Signal?
title Electromyographic Activity in the EEG in Alzheimer's Disease: Noise or Signal?
title_full Electromyographic Activity in the EEG in Alzheimer's Disease: Noise or Signal?
title_fullStr Electromyographic Activity in the EEG in Alzheimer's Disease: Noise or Signal?
title_full_unstemmed Electromyographic Activity in the EEG in Alzheimer's Disease: Noise or Signal?
title_short Electromyographic Activity in the EEG in Alzheimer's Disease: Noise or Signal?
title_sort electromyographic activity in the eeg in alzheimer's disease: noise or signal?
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089836/
https://www.ncbi.nlm.nih.gov/pubmed/21559240
http://dx.doi.org/10.4061/2011/547024
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