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Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation

Recruitment of leukocytes circulating in our blood to the sites of infection or tissue damage is the key phenomenon in the acute inflammatory response(s). Among the leukocytes, neutrophils are primarily recruited into the areas of acute inflammation. When neutrophils interact with activated endothel...

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Autores principales: Kumar, Srinivasan Dinesh, Krishnamurthy, Kandamaran, Manikandan, Jayapal, Pakeerappa, Praveen N, Pushparaj, Peter Natesan
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089884/
https://www.ncbi.nlm.nih.gov/pubmed/21584186
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author Kumar, Srinivasan Dinesh
Krishnamurthy, Kandamaran
Manikandan, Jayapal
Pakeerappa, Praveen N
Pushparaj, Peter Natesan
author_facet Kumar, Srinivasan Dinesh
Krishnamurthy, Kandamaran
Manikandan, Jayapal
Pakeerappa, Praveen N
Pushparaj, Peter Natesan
author_sort Kumar, Srinivasan Dinesh
collection PubMed
description Recruitment of leukocytes circulating in our blood to the sites of infection or tissue damage is the key phenomenon in the acute inflammatory response(s). Among the leukocytes, neutrophils are primarily recruited into the areas of acute inflammation. When neutrophils interact with activated endothelium of the blood vessels, they become migratory and cross the endothelial layer of the blood vessel wall in a process called as leukocyte extravasation. Identifying and understanding the gene regulation of this extravasation phenomenon is one of the key objective of biomedical research aimed at ameliorating or alleviating the symptoms of various diseases, such as rheumatoid arthritis, asthma, anaphylaxis, atherosclerosis, ulcerative colitis etc., that are exacerbated by inappropriate inflammatory stimuli. Here, we decipher and discuss the key genes implicated in the leukocyte transmigration using the acute inflammation model called as the Dextran Sulphate Sodium (DSS) induced Colitis in mice as a classic paradigm.
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spelling pubmed-30898842011-05-16 Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation Kumar, Srinivasan Dinesh Krishnamurthy, Kandamaran Manikandan, Jayapal Pakeerappa, Praveen N Pushparaj, Peter Natesan Bioinformation Hypothesis Recruitment of leukocytes circulating in our blood to the sites of infection or tissue damage is the key phenomenon in the acute inflammatory response(s). Among the leukocytes, neutrophils are primarily recruited into the areas of acute inflammation. When neutrophils interact with activated endothelium of the blood vessels, they become migratory and cross the endothelial layer of the blood vessel wall in a process called as leukocyte extravasation. Identifying and understanding the gene regulation of this extravasation phenomenon is one of the key objective of biomedical research aimed at ameliorating or alleviating the symptoms of various diseases, such as rheumatoid arthritis, asthma, anaphylaxis, atherosclerosis, ulcerative colitis etc., that are exacerbated by inappropriate inflammatory stimuli. Here, we decipher and discuss the key genes implicated in the leukocyte transmigration using the acute inflammation model called as the Dextran Sulphate Sodium (DSS) induced Colitis in mice as a classic paradigm. Biomedical Informatics 2011-04-22 /pmc/articles/PMC3089884/ /pubmed/21584186 Text en © 2011 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Kumar, Srinivasan Dinesh
Krishnamurthy, Kandamaran
Manikandan, Jayapal
Pakeerappa, Praveen N
Pushparaj, Peter Natesan
Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation
title Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation
title_full Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation
title_fullStr Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation
title_full_unstemmed Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation
title_short Deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation
title_sort deciphering the key molecular and cellular events in neutrophil transmigration during acute inflammation
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089884/
https://www.ncbi.nlm.nih.gov/pubmed/21584186
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