The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases

We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient Conserved Region’ of CMN mycolyltransferases. The evo...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramulu, Hemalatha G., Swathi, Adindla, Guruprasad, Lalitha
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089981/
https://www.ncbi.nlm.nih.gov/pubmed/21760704
_version_ 1782203100395732992
author Ramulu, Hemalatha G.
Swathi, Adindla
Guruprasad, Lalitha
author_facet Ramulu, Hemalatha G.
Swathi, Adindla
Guruprasad, Lalitha
author_sort Ramulu, Hemalatha G.
collection PubMed
description We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient Conserved Region’ of CMN mycolyltransferases. The evolutionary trace analysis suggests that twelve amino acid residues; Leu39, Trp51, Pro71, Trp82, Trp97, Phe100, Gly124, Ser126, Asp192, Glu230, Gly260 and Trp264 are ‘absolutely conserved’. These amino acid residues constitute the active site and conserved hydrophobic tunnel in CMN mycolyltransferases.
format Text
id pubmed-3089981
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Libertas Academica
record_format MEDLINE/PubMed
spelling pubmed-30899812011-05-11 The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases Ramulu, Hemalatha G. Swathi, Adindla Guruprasad, Lalitha Evol Bioinform Online Original Research We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient Conserved Region’ of CMN mycolyltransferases. The evolutionary trace analysis suggests that twelve amino acid residues; Leu39, Trp51, Pro71, Trp82, Trp97, Phe100, Gly124, Ser126, Asp192, Glu230, Gly260 and Trp264 are ‘absolutely conserved’. These amino acid residues constitute the active site and conserved hydrophobic tunnel in CMN mycolyltransferases. Libertas Academica 2007-02-27 /pmc/articles/PMC3089981/ /pubmed/21760704 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Original Research
Ramulu, Hemalatha G.
Swathi, Adindla
Guruprasad, Lalitha
The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases
title The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases
title_full The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases
title_fullStr The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases
title_full_unstemmed The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases
title_short The Rv3799–Rv3807 gene cluster in Mycobacterium tuberculosis genome corresponds to the ‘Ancient Conserved Region’ in CMN mycolyltransferases
title_sort rv3799–rv3807 gene cluster in mycobacterium tuberculosis genome corresponds to the ‘ancient conserved region’ in cmn mycolyltransferases
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089981/
https://www.ncbi.nlm.nih.gov/pubmed/21760704
work_keys_str_mv AT ramuluhemalathag therv3799rv3807geneclusterinmycobacteriumtuberculosisgenomecorrespondstotheancientconservedregionincmnmycolyltransferases
AT swathiadindla therv3799rv3807geneclusterinmycobacteriumtuberculosisgenomecorrespondstotheancientconservedregionincmnmycolyltransferases
AT guruprasadlalitha therv3799rv3807geneclusterinmycobacteriumtuberculosisgenomecorrespondstotheancientconservedregionincmnmycolyltransferases
AT ramuluhemalathag rv3799rv3807geneclusterinmycobacteriumtuberculosisgenomecorrespondstotheancientconservedregionincmnmycolyltransferases
AT swathiadindla rv3799rv3807geneclusterinmycobacteriumtuberculosisgenomecorrespondstotheancientconservedregionincmnmycolyltransferases
AT guruprasadlalitha rv3799rv3807geneclusterinmycobacteriumtuberculosisgenomecorrespondstotheancientconservedregionincmnmycolyltransferases

Ejemplares similares