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Immunobiological properties of selected natural and chemically modified phenylpropanoids
Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murine resident peritoneal macrophages, are reviewed. Relation betw...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Slovak Toxicology Society SETOX
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090047/ https://www.ncbi.nlm.nih.gov/pubmed/21577277 http://dx.doi.org/10.2478/v10102-011-0002-1 |
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author | Harmatha, Juraj Zídek, Zdeněk Kmoníčková, Eva Šmidrkal, Jan |
author_facet | Harmatha, Juraj Zídek, Zdeněk Kmoníčková, Eva Šmidrkal, Jan |
author_sort | Harmatha, Juraj |
collection | PubMed |
description | Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murine resident peritoneal macrophages, are reviewed. Relation between the molecular structure and immunobiological activity was investigated, and implication of substituents, double bond stereochemistry, or cyclic attachments (double bond geometry fixation) was assessed. The focus was on lignans and stilbenoids because they were originally selected for a joint project of common interest to phytochemical and pharmacological investigation and because they represent well interesting and universally attractive groups of polyphenols with a feasible potential for therapeutic or nutraceutic utilization. |
format | Text |
id | pubmed-3090047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Slovak Toxicology Society SETOX |
record_format | MEDLINE/PubMed |
spelling | pubmed-30900472011-05-16 Immunobiological properties of selected natural and chemically modified phenylpropanoids Harmatha, Juraj Zídek, Zdeněk Kmoníčková, Eva Šmidrkal, Jan Interdiscip Toxicol Review Article Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murine resident peritoneal macrophages, are reviewed. Relation between the molecular structure and immunobiological activity was investigated, and implication of substituents, double bond stereochemistry, or cyclic attachments (double bond geometry fixation) was assessed. The focus was on lignans and stilbenoids because they were originally selected for a joint project of common interest to phytochemical and pharmacological investigation and because they represent well interesting and universally attractive groups of polyphenols with a feasible potential for therapeutic or nutraceutic utilization. Slovak Toxicology Society SETOX 2011-03 2011-03 /pmc/articles/PMC3090047/ /pubmed/21577277 http://dx.doi.org/10.2478/v10102-011-0002-1 Text en Copyright © 2011 Slovak Toxicology Society SETOX http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Harmatha, Juraj Zídek, Zdeněk Kmoníčková, Eva Šmidrkal, Jan Immunobiological properties of selected natural and chemically modified phenylpropanoids |
title | Immunobiological properties of selected natural and chemically modified phenylpropanoids |
title_full | Immunobiological properties of selected natural and chemically modified phenylpropanoids |
title_fullStr | Immunobiological properties of selected natural and chemically modified phenylpropanoids |
title_full_unstemmed | Immunobiological properties of selected natural and chemically modified phenylpropanoids |
title_short | Immunobiological properties of selected natural and chemically modified phenylpropanoids |
title_sort | immunobiological properties of selected natural and chemically modified phenylpropanoids |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090047/ https://www.ncbi.nlm.nih.gov/pubmed/21577277 http://dx.doi.org/10.2478/v10102-011-0002-1 |
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