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Immunobiological properties of selected natural and chemically modified phenylpropanoids

Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murine resident peritoneal macrophages, are reviewed. Relation betw...

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Autores principales: Harmatha, Juraj, Zídek, Zdeněk, Kmoníčková, Eva, Šmidrkal, Jan
Formato: Texto
Lenguaje:English
Publicado: Slovak Toxicology Society SETOX 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090047/
https://www.ncbi.nlm.nih.gov/pubmed/21577277
http://dx.doi.org/10.2478/v10102-011-0002-1
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author Harmatha, Juraj
Zídek, Zdeněk
Kmoníčková, Eva
Šmidrkal, Jan
author_facet Harmatha, Juraj
Zídek, Zdeněk
Kmoníčková, Eva
Šmidrkal, Jan
author_sort Harmatha, Juraj
collection PubMed
description Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murine resident peritoneal macrophages, are reviewed. Relation between the molecular structure and immunobiological activity was investigated, and implication of substituents, double bond stereochemistry, or cyclic attachments (double bond geometry fixation) was assessed. The focus was on lignans and stilbenoids because they were originally selected for a joint project of common interest to phytochemical and pharmacological investigation and because they represent well interesting and universally attractive groups of polyphenols with a feasible potential for therapeutic or nutraceutic utilization.
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spelling pubmed-30900472011-05-16 Immunobiological properties of selected natural and chemically modified phenylpropanoids Harmatha, Juraj Zídek, Zdeněk Kmoníčková, Eva Šmidrkal, Jan Interdiscip Toxicol Review Article Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murine resident peritoneal macrophages, are reviewed. Relation between the molecular structure and immunobiological activity was investigated, and implication of substituents, double bond stereochemistry, or cyclic attachments (double bond geometry fixation) was assessed. The focus was on lignans and stilbenoids because they were originally selected for a joint project of common interest to phytochemical and pharmacological investigation and because they represent well interesting and universally attractive groups of polyphenols with a feasible potential for therapeutic or nutraceutic utilization. Slovak Toxicology Society SETOX 2011-03 2011-03 /pmc/articles/PMC3090047/ /pubmed/21577277 http://dx.doi.org/10.2478/v10102-011-0002-1 Text en Copyright © 2011 Slovak Toxicology Society SETOX http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Harmatha, Juraj
Zídek, Zdeněk
Kmoníčková, Eva
Šmidrkal, Jan
Immunobiological properties of selected natural and chemically modified phenylpropanoids
title Immunobiological properties of selected natural and chemically modified phenylpropanoids
title_full Immunobiological properties of selected natural and chemically modified phenylpropanoids
title_fullStr Immunobiological properties of selected natural and chemically modified phenylpropanoids
title_full_unstemmed Immunobiological properties of selected natural and chemically modified phenylpropanoids
title_short Immunobiological properties of selected natural and chemically modified phenylpropanoids
title_sort immunobiological properties of selected natural and chemically modified phenylpropanoids
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090047/
https://www.ncbi.nlm.nih.gov/pubmed/21577277
http://dx.doi.org/10.2478/v10102-011-0002-1
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